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Table 4 Association of maternal genetic risk scores with offspring IQ at age 8

From: Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children

Genetic risk score

N (unadjusted/adjusted)

Mean difference in IQ per weighted allele (95% CI)

p-value

Adjusted by offspring score and PCs

p-value

FGGRS

2732/1374

−0.03 (−0.24, 0.17)

0.74

0.20 (−0.14, 0.53)

0.26

T2DGRS

2423/1102

0.16 (−0.04, 0.36)

0.12

0.47 (0.12, 0.81)

0.01

  1. FGGRS = fasting glucose genetic risk score.
  2. T2DGRS = type 2 diabetes genetic risk score.
  3. PCs = population stratification principal components.