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Table 1 Genetic variants related to fasting glucose concentration and type 2 diabetes examined in this study

From: Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children

Gene

dbSNP id

Alleles (major/minor)

MAF mothers N = 6844*

MAF children N = 7685*

CEU†

Risk allele‡

Reported associations

ADAMTS9

rs4607103

C/T

0.24

0.24

0.19

major

T2D

ADCY5

rs2877716

C/T

0.26

0.26

0.25

major

fasting glucose/T2D

ADIPOQ

rs1501299

G/T

n/t

0.27

0.27

minor

T2D

ADIPOQ

rs17300539

G/A

n/t

0.09

0.08

minor

T2D

ADIPOQ

rs266729

C/G

n/t

0.26

0.31

minor

T2D

ADRA2A

rs10885122

G/T

0.13

0.12

0.10

major

fasting glucose

C2CD4B

rs11071657

A/G

0.39

0.38

0.41

major

fasting glucose

CDC123/CAMK1D

rs12779790

A/G

0.18

0.19

0.22

minor

T2D

CDKAL1

rs10946398

A/C

0.31

0.31

0.30

minor

T2D

CDKN2A/B

rs10811661

T/C

0.18

0.17

0.20

major

T2D

COX2

rs20417

G/C

0.15

0.15

0.18

major

T2D

CRY2

rs11605924

C/A

0.48

0.48

0.54

minor

fasting glucose

DGKB/TMEM195

rs2191349

T/G

0.46

0.46

0.53

major

fasting glucose/T2D

FADS1

rs174550

T/C

0.33

0.33

0.37

major

fasting glucose

FTO

rs9939609

T/A

0.40

0.40

0.45

minor

obesity

G6PC2

rs560887

C/T

0.30

0.30

0.33

major

fasting glucose

GCK

rs1799884

G/A

0.18

0.18

0.20

minor

fasting glucose/T2D

GCKR

rs780094

C/T

0.39

0.39

0.38

major

fasting glucose/T2D

GLIS3

rs7034200

C/A

0.47

0.48

0.53

minor

fasting glucose

HHEX-IDE

rs1111875

C/T

0.41

0.41

0.44

major

T2D

HNF1B

rs757210

C/T

0.37

0.37

0.43

minor

T2D

IGF2BP2

rs4402690

G/T

0.31

0.30

0.29

minor

T2D

JAZF1

rs864745

A/G

0.50

0.50

0.48

major

T2D

KCNJ11

rs5219

C/T

0.35

0.35

0.50

minor

T2D

KCNQ1

rs2237892

C/T

0.06

0.06

0.08

major

T2D

KCNQ1

rs2237895

A/C

0.42

0.41

0.36

minor

T2D

MADD

rs7944584

A/T

0.28

0.28

0.29

major

fasting glucose

MTNR1B

rs10830963

C/G

0.27

0.28

0.30

minor

fasting glucose/T2D

NOTCH2

rs10923931

G/T

0.11

0.11

0.09

minor

T2D

PPARG

rs1801282

C/G

0.12

0.11

0.07

major

T2D

PROX1

rs340874

C/T

0.43

0.43

0.44

major

fasting glucose/T2D

SLC2A2

rs11920090

T/A

0.12

0.13

0.13

major

fasting glucose

SLC30A8

rs13266634

C/T

0.30

0.30

0.25

major

fasting glucose/T2D

TCF7L2

rs12255372

G/T

0.29

0.29

0.22

minor

fasting glucose

TCF7L2

rs7903146

C/T

0.30

0.30

0.25

minor

fasting glucose/T2D

THADA

rs7578597

A/G

0.11

0.11

0.08

major

T2D

TSPAN8/LGR5

rs7961581

T/C

0.28

0.28

0.23

minor

T2D

WFS1

rs10010131

G/A

0.40

0.40

0.26

major

T2D

  1. MAF = minor allele frequency.
  2. T2D = type 2 diabetes.
  3. n/t = not typed.
  4. *N = mean of the total number of individuals typed for each SNP. Range in mothers: 2553–7151. Range in children: 7295–8323.
  5. †minor allele frequency in the HapMap CEPH European population.
  6. ‡risk allele for higher plasma fasting glucose or susceptibility to type 2 diabetes.