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Table 5 Variance-components and hazard ratio estimates for age-at-onset of regular cigarette use in Brazilian families.

From: Genetic analyses of smoking initiation, persistence, quantity, and age-at-onset of regular cigarette use in Brazilian families: the Baependi Heart Study

Model

No heterogeneity

Heterogeneity in variance components by gender

 

Hazard ratio

Variance components

Hazard ratio

Variance components

 

Sex

σ2 g

σ2 f

Sex

σ2 g,m

σ2 g,f

σ2 f

Polygenic

0.43***

0.58

 

0.43***

0.21

0.40

 
  

(0.33-0.91)

  

(0.01-0.54)

(0.11-0.78)

 

Polygenic and shared family

0.43***

0.37

0.17

0.42***

0.03

0.28

0.25

  

(0.14-0.70)

(0.05-0.39)

 

(0.00-0.35)

(0.01-0.65)

(0.12-0.48)

  1. ***p ≤ 0.001; σ2 g: polygenic variance estimate; σ2 g,m: polygenic variance estimate for males; σ2 g,f: polygenic variance estimate for females; σ2 f: variance estimate for shared family effect.
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BMC Medical Genetics

ISSN: 1471-2350

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