Transferability and Fine Mapping of genome-wide associated loci for lipids in African Americans

BMC Medical Genetics

Table 3 Local replication of previously reported GWAS associations ¹ in a cohort of African Americans

Index SNP	Local SNP	R²	Chr	Position	Minor Allele (Freq HUFS, Freq CEU)	Nearby Gene	Trait	Local SNP Values)
Index SNP	Local SNP	R²	Chr	Position	Minor Allele (Freq HUFS, Freq CEU)	Nearby Gene	Trait	Beta (SE)	P-value²
rs2972146	rs2943652	1	2	226816690	C (0.38, 0.40)	IRS1	HDL	3.0 (1.1)	0.01
rs3764261	rs173539	1	16	55545545	T (0.30, 0.37)	CETP	HDL	4.3 (1.2)	0.0003
	rs1800775	0.5	16	55552737	C (0.45, 0.49)	CETP	HDL	−2.5 (1.0)	0.03
	rs4783961	0.6	16	55552395	A (0.37, 0.51)	CETP	HDL	4.6 (1.3)	0.0009
rs7941030	rs6589939	0.9	11	122023735	G (0.35, 0.39)	UBASH3B	TC	−6.7 (2.1)	0.005

¹Teslovich et al., Nature, 2010; ² P-values have been adjusted for the effective degrees of freedom within the LD window surrounding the index SNP.

ISSN: 1471-2350