| No. of | Normals (% met) | Hypermethylation | Tumors (% met) | Tumors > cut-off | |||
---|---|---|---|---|---|---|---|---|
 | CpGs | mean | range | cut-off (% met) | mean | range | NB | Gang |
Genes with detected hypermethylation | ||||||||
BLU | 8 | 4 | (3-4) | >10 | 7 | (2-65) | 4 | 0 |
CASP8 - A1 | 4 | 1 | (0-3) | >10 | 16 | (0-52) | 21 | 0 |
CASP8 - A2 | 5 | 36 | (24-41) | >50 | 42 | (15-64) | 9 | 0 |
DCR2 | 9 | 18 | (10-21) | >30 | 12 | (0-67) | 5 | 0 |
CDH1 | 9 | 4 | (4-5) | >10 | 3 | (1-12) | 1 | 0 |
RASSF1A | 5 | 13 | (8-21) | >30 | 43 | (1-89) | 23 | 0 |
RASSF2 | 6 | 6 | (4-8) | >10 | 6 | (3-11) | 1 | 0 |
Genes without detected hypermethylation | ||||||||
APC | 10 | 2 | (1-4) | >10 | 1 | (0-2) | 0 | 0 |
DAPK1 | 13 | 1 | (0-1) | >10 | 0 | (0-1) | 0 | 0 |
NORE1A* | 13 | 1 | (1-3) | >10 | 1 | (0-3) | 0 | 0 |
P14 | 13 | 5 | (2-11) | >10 | 1 | (0-3) | 0 | 0 |
P16 | 4 | 1 | (0-1) | >10 | 0 | (0-1) | 0 | 0 |
TP73 | 19 | 1 | (1-2) | >10 | 1 | (0-2) | 0 | 0 |
PTEN | 10 | 1 | (1-1) | >10 | 1 | (0-1) | 0 | 0 |
RARB | 10 | 6 | (5-7) | >10 | 2 | (0-5) | 0 | 0 |
Global methylation | ||||||||
LINE-1 | multiple | 67.7 | (65.6-70.3) | - | 64.1 | (53.9-74.8) | Â | Â |