Skip to main content

Table 1 Overview of methylation levels in normals and primary tumors

From: Quantitative global and gene-specific promoter methylation in relation to biological properties of neuroblastomas

 

No. of

Normals (% met)

Hypermethylation

Tumors (% met)

Tumors > cut-off

 

CpGs

mean

range

cut-off (% met)

mean

range

NB

Gang

Genes with detected hypermethylation

BLU

8

4

(3-4)

>10

7

(2-65)

4

0

CASP8 - A1

4

1

(0-3)

>10

16

(0-52)

21

0

CASP8 - A2

5

36

(24-41)

>50

42

(15-64)

9

0

DCR2

9

18

(10-21)

>30

12

(0-67)

5

0

CDH1

9

4

(4-5)

>10

3

(1-12)

1

0

RASSF1A

5

13

(8-21)

>30

43

(1-89)

23

0

RASSF2

6

6

(4-8)

>10

6

(3-11)

1

0

Genes without detected hypermethylation

APC

10

2

(1-4)

>10

1

(0-2)

0

0

DAPK1

13

1

(0-1)

>10

0

(0-1)

0

0

NORE1A*

13

1

(1-3)

>10

1

(0-3)

0

0

P14

13

5

(2-11)

>10

1

(0-3)

0

0

P16

4

1

(0-1)

>10

0

(0-1)

0

0

TP73

19

1

(1-2)

>10

1

(0-2)

0

0

PTEN

10

1

(1-1)

>10

1

(0-1)

0

0

RARB

10

6

(5-7)

>10

2

(0-5)

0

0

Global methylation

LINE-1

multiple

67.7

(65.6-70.3)

-

64.1

(53.9-74.8)

  
  1. NB = Neuroblastoma; Gang = Ganglioneuroma.
  2. * previously published in [32]. (Geli et al. 2008).