Figure 3

CpG hypermethylation at the two reported regulatory regions of the CASP8 gene. Methylation densities detected at the CpGs assayed in the respective locations CASP8 A1 and CASP8 A2 are shown at the top, where filled diamonds represent hypermethylated tumors and open diamonds indicate unmethylated tumors. The cut-off levels >10 % for CASP8 A1 and >50 % for CASP8 A2 are marked by dotted lines. The diagram at the bottom illustrates the relationship between mean methylation levels of CASP8 A1 (filled staples) and CASP8 A2 (open staples) in all samples analyzed including tumors, references and cell lines.