Skip to main content

Advertisement

Table 1 ORs and heterogeneity results for the genetic contrasts of MTHFR C677T polymorphism for ALL risk

From: Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia-Evidence from an updated meta-analysis including 35 studies

  Genetic Model Studies I 2, (%) P, Q Testa Fixed-effect Random-effect
OR OR
All Allele contrast 34 58 0.000 0.92(0.88-0.97) 0.91(0.83-0.99)
  Dominant model 34 58 0.000 0.92(0.86-0.98) 0.90(0.80-1.02)
  Recessive model 33 22 0.129 0.86(0.77-0.96) 0.85(0.74-0.98)
  Additive mode 33 39 0.013 0.82(0.73-0.93) 0.80(0.68-0.95)
All in HWE Allele contrast 31 61 0.000 0.92(0.87-0.97) 0.90(0.82-0.99)
  Dominant model 31 60 0.000 0.92(0.86-0.99) 0.90(0.80-1.02)
  Recessive model 30 25 0.109 0.85(0.76-0.96) 0.84(0.72-0.97)
  Additive model 30 41 0.011 0.82(0.72-0.92) 0.78(0.65-0.94)
Children Allele contrast 25 56 0.000 0.92(0.87-0.98) 0.90(0.82-0.997)
  Dominant model 25 60 0.000 0.92(0.85-0.99) 0.90(0.79-1.03)
  Recessive model 24 0 0.479 0.85(0.74-0.96) 0.86(0.75-0.98)
  Additive model 24 23 0.158 0.82(0.71-0.94) 0.80(0.67-0.95)
Adults Allele contrast 6 75 0.001 0.95(0.83-1.09) 0.95(0.71-1.26)
  Dominant model 6 67 0.010 0.94(0.77-1.14) 0.96(0.68-1.35)
  Recessive model 6 66 0.012 0.93(0.72-1.22) 0.85(0.52-1.40)
  Additive model 6 74 0.002 0.89(0.67-1.19) 0.82(0.44-1.52)
Adults+children Allele contrast 3 40 0.187 0.88(0.72-1.06) 0.89(0.69-1.14)
  Dominant model 3 52 0.126 0.85(0.64-1.12) 0.86(0.57-1.29)
  Recessive model 3 31 0.236 0.85(0.60-1.20) 0.85(0.55-1.39)
  Additive model 3 30 0.241 0.77(0.52-1.14) 0.79(0.49-1.26)
East Asians Allele contrast 7 65 0.009 0.92(0.83-1.02) 0.95(0.79-1.15)
  Dominant model 7 60 0.020 0.90(0.78-1.04) 0.95(0.74-1.22)
  Recessive model 7 53 0.047 0.89(0.72-1.09) 0.91(0.66-1.24)
  Additive model 7 60 0.020 0.87(0.69-1.09) 0.90(0.62-1.32)
Caucasians Allele contrast 15 54 0.006 0.89(0.83-0.96) 0.85(0.76-0.95)
  Dominant model 15 54 0.007 0.88(0.80-0.96) 0.82(0.70-0.95)
  Recessive model 15 27 0.155 0.85(0.73-0.98) 0.82(0.68-0.99)
  Additive model 15 40 0.053 0.80(0.69-0.93) 0.74(0.59-0.92)
  1. All = all of the studies meet the inclusion criteria; All in HWE = all of the studies meet the inclusion criteria except ones with genotype distribution of the controls deviating from HWE; HWE = Hardy-Weinberg Equilibrium.
  2. a Q test is to estimate heterogeneity between studies. P < 0.10 indicates significant heterogeneity.