Skip to main content

Table 1 ORs and heterogeneity results for the genetic contrasts of MTHFR C677T polymorphism for ALL risk

From: Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia-Evidence from an updated meta-analysis including 35 studies

 

Genetic Model

Studies

I 2, (%)

P, Q Testa

Fixed-effect

Random-effect

OR

OR

All

Allele contrast

34

58

0.000

0.92(0.88-0.97)

0.91(0.83-0.99)

 

Dominant model

34

58

0.000

0.92(0.86-0.98)

0.90(0.80-1.02)

 

Recessive model

33

22

0.129

0.86(0.77-0.96)

0.85(0.74-0.98)

 

Additive mode

33

39

0.013

0.82(0.73-0.93)

0.80(0.68-0.95)

All in HWE

Allele contrast

31

61

0.000

0.92(0.87-0.97)

0.90(0.82-0.99)

 

Dominant model

31

60

0.000

0.92(0.86-0.99)

0.90(0.80-1.02)

 

Recessive model

30

25

0.109

0.85(0.76-0.96)

0.84(0.72-0.97)

 

Additive model

30

41

0.011

0.82(0.72-0.92)

0.78(0.65-0.94)

Children

Allele contrast

25

56

0.000

0.92(0.87-0.98)

0.90(0.82-0.997)

 

Dominant model

25

60

0.000

0.92(0.85-0.99)

0.90(0.79-1.03)

 

Recessive model

24

0

0.479

0.85(0.74-0.96)

0.86(0.75-0.98)

 

Additive model

24

23

0.158

0.82(0.71-0.94)

0.80(0.67-0.95)

Adults

Allele contrast

6

75

0.001

0.95(0.83-1.09)

0.95(0.71-1.26)

 

Dominant model

6

67

0.010

0.94(0.77-1.14)

0.96(0.68-1.35)

 

Recessive model

6

66

0.012

0.93(0.72-1.22)

0.85(0.52-1.40)

 

Additive model

6

74

0.002

0.89(0.67-1.19)

0.82(0.44-1.52)

Adults+children

Allele contrast

3

40

0.187

0.88(0.72-1.06)

0.89(0.69-1.14)

 

Dominant model

3

52

0.126

0.85(0.64-1.12)

0.86(0.57-1.29)

 

Recessive model

3

31

0.236

0.85(0.60-1.20)

0.85(0.55-1.39)

 

Additive model

3

30

0.241

0.77(0.52-1.14)

0.79(0.49-1.26)

East Asians

Allele contrast

7

65

0.009

0.92(0.83-1.02)

0.95(0.79-1.15)

 

Dominant model

7

60

0.020

0.90(0.78-1.04)

0.95(0.74-1.22)

 

Recessive model

7

53

0.047

0.89(0.72-1.09)

0.91(0.66-1.24)

 

Additive model

7

60

0.020

0.87(0.69-1.09)

0.90(0.62-1.32)

Caucasians

Allele contrast

15

54

0.006

0.89(0.83-0.96)

0.85(0.76-0.95)

 

Dominant model

15

54

0.007

0.88(0.80-0.96)

0.82(0.70-0.95)

 

Recessive model

15

27

0.155

0.85(0.73-0.98)

0.82(0.68-0.99)

 

Additive model

15

40

0.053

0.80(0.69-0.93)

0.74(0.59-0.92)

  1. All = all of the studies meet the inclusion criteria; All in HWE = all of the studies meet the inclusion criteria except ones with genotype distribution of the controls deviating from HWE; HWE = Hardy-Weinberg Equilibrium.
  2. a Q test is to estimate heterogeneity between studies. P < 0.10 indicates significant heterogeneity.
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us