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Table 3 Summary of the JAK2 genotype in MPN patients

From: The C allele of JAK2 rs4495487 is an additional candidate locus that contributes to myeloproliferative neoplasm predisposition in the Japanese population

 

GCC genotype

non-GCC genotype

P(Chi-square test)

Odds ratio

95% CI

Case Population

46/1 haplotype rs4495987(+)

non-46/1 haplotype rs4495987(-)

   

JAK2V617F-positive PV (n = 33)

22

11

0.0023

3.63

1.59-8.29

JAK2V617F-positive ET (n = 57)

35

22

0.0043

2.72

1.40-5.32

JAK2V617F-negative ET (n = 39)

24

15

0.0076

2.91

1.36-6.19

JAK2V617F-positive MPN (n = 95)

60

35

0.0001

3.07

1.73-5.46

JAK2V617F-negative MPN (n = 43)

24

19

0.0289

2.26

1.01-4.70

Control: non-MPN (n = 107)

38

69

   
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BMC Medical Genetics

ISSN: 1471-2350

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