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Table 2 Distributions of IL17A genotypes and gene mathylations

From: Influence of IL17A polymorphisms on the aberrant methylation of DAPK and CDH1 in non-cancerous gastric mucosa

 

DAPK

CDH1

 

Unmethylated

methylated

p value*

unmethylated

methylated

p value*

number of subjects

205

196

 

252

149

 

mean age ± SD

59.3 ± 13.6

60.8 ± 13.9

NS

60.1 ± 14.1

59.9 ± 13.2

NS

male : female

118 : 87

112 : 84

NS

145 : 107

85 : 64

NS

H. pylori positive rate

104/205

137/196

<0.0001

131/252

110/149

<0.0001

-197 G > A

      

GG

86

69

98

57

  

GA

99

105

128

76

  

AA

19

22

26

15

  

(unknown)

1

0

0

1

  

A allele frequency

33.6%

38.0%

NS

35.7%

35.8%

NS

*1249 C > T

      

CC

167

173

0.023a

210

130

 

CT

28

14

 

28

14

 

TT

10

6

11

5

  

(unknown)

0

3

 

3

0

 

T allele frequency11.

7%

6.7%

0.020

10.0%

8.2% NS

 
  1. *: unmethylated vs. methylated.
  2. a: frequency of *1249 CC genotype.