Table 3 Association between RNLS rs2576178 A > G and rs2296545 C > G polymorphisms and BP according to different genetic models
RNLS rs2576178 | ||||||
|---|---|---|---|---|---|---|
Genetic model | ||||||
Type of blood pressure adjustment for AHT | Additive | p-value | Autosomal recessive | p-value | Autosomal dominant | p-value |
Crude (non adjusted) | ||||||
SBP (mmHg) | −0.311 (0.365) | 0.39 | 0.552 (0.863) | 0.52 | −0.669 (0.467) | 0.15 |
DBP (mmHg) | 0.074 (0.187) | 0.69 | 0.491 (0.442) | 0.27 | −0.023 (0.239) | 0.92 |
Fixed addition | ||||||
SBP (mmHg) | −0.254 (0.386) | 0.51 | 0.492 (0.913) | 0.59 | −0.558 (0.494) | 0.26 |
DBP (mmHg) | 0.102 (0.198) | 0.60 | 0.461 (0.467) | 0.32 | 0.032 (0.253) | 0.90 |
Stepped addition | ||||||
SBP (mmHg) | −0.297 (0.387) | 0.44 | 0.477 (0.915) | 0.60 | −0.625 (0.495) | 0.21 |
DBP (mmHg) | 0.065 (0.202) | 0.75 | 0.429 (0.478) | 0.37 | −0.019 (0.259) | 0.94 |
RNLS rs2296545 | ||||||
Type of blood pressure adjustment for AHT | Additive | p-value | Autosomal recessive | p-value | Autosomal dominant | p-value |
Crude (non adjusted) | ||||||
SBP (mmHg) | 0.075 (0.332) | 0.82 | 0.336 (0.575) | 0.56 | −0.087 (0.513) | 0.87 |
DBP (mmHg) | −0.118 (0.170) | 0.49 | −0.143 (0.294) | 0.63 | −0.168 (0.262) | 0.52 |
Fixed addition | ||||||
SBP (mmHg) | −0.022 (0.351) | 0.95 | 0.249 (0.609) | 0.68 | −0.251 (0.543) | 0.64 |
DBP (mmHg) | −0.167 (0.179) | 0.35 | −0.187 (0.311) | 0.55 | −0.250 (0.277) | 0.37 |
Stepped addition | ||||||
SBP (mmHg) | 0.033 (0.352) | 0.93 | 0.336 (0.610 | 0.58 | −0.188 (0.544) | 0.73 |
DBP (mmHg) | −0.124 (0.183) | 0.50 | −0.099 (0.318) | 0.76 | −0.217 (0.284) | 0.44 |