Figure 1
From: Identification of 3 novel VHL germ-line mutations in Danish VHL patients
von Hippel-Lindau gene and protein structure. A) The VHL gene comprises three exons (gray). Nucleotide number is indicated above the gene structure. B) The VHL protein structure with (GXEEX)8 repeat motif (pink), Ī±-domain (purple) and Ī²-domain (blue). Codon number is indicated below the protein structure. The eleven residues subjected for missense mutations are indicated below the figure.