From: SNP-set analysis replicates acute lung injury genetic risk factors
Candidate Gene (gene symbol) | # SNPs AA | # SNPs EA | ALI Risk Factor | Ancestry | Ref |
---|---|---|---|---|---|
Angiotensin converting enzyme (ACE) | 39 | 24 | Mixed ICU | Eur | 3,5 |
Angiopoietin-2 (ANGPT2) | 63 | 52 | Trauma | Afr, Eur | 13, 35 |
Chemokine (CXC motif) ligand 2 (CXCL2) | 5 | 4 | Sepsis | Eur | 3,5 |
Epidermal growth factor (EGF) | 36 | 20 | Mixed ICU; Sepsis | Eur | 34 |
Factor V (F5) | 84 | 77 | Mixed ICU | Eur | 3,5 |
FAS (FAS, TNF receptor superfamily, member 6) | 27 | 18 | Mixed ICU; SIRS | Eur | 16 |
Interleukin-6 (IL6) | 15 | 10 | Mixed ICU; sepsis | Eur | 3,5,40 |
Interleukin-8 (IL8) | 9 | 7 | Trauma | Eur | 3,5 |
Interleukin-10 (IL10) | 5 | 9 | Mixed ICU; trauma | Eur | 3,5,38 |
Interleukin-1 receptor associated kinase 3 (IRAK3) | 25 | 22 | Sepsis | Eur | 14 |
Mannose binding lectin (MBL2) | 7 | 9 | Mixed ICU | Eur, Chi | 3,5 |
Macrophage migration inhibitory factor (MIF) | 1 | 1 | Sepsis | Eur, Afr | 3,5 |
Myosin light chain kinase (MYLK) | 10 | 8 | Sepsis; trauma | Eur, Afr | 3,5 |
NAD(P)H dehydrogenase, quinone 1 (NQO1) | 14 | 11 | Trauma | Eur | 3 |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1) | 57 | 54 | Mixed ICU | Eur | 3,5 |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA) | 14 | 18 | Mixed ICU | Eur | 3,5,39 |
Nuclear factor (erythroid-derived 2-like) 2 (NFE2L2) | 19 | 16 | Trauma | Eur | 3,5 |
Pre-B-cell colony enhancing factor (PBEF1) | 7 | 5 | Sepsis; mixed ICU | Eur | 3,5 |
Plasminogen activator, urokinase (PLAU) | 2 | 2 | Sepsis; pneumonia | Eur | 3,5 |
Plasminogen activator inhibitor type 1 (SERPINE1) | 14 | 8 | Pneumonia | Multi | 15 |
Superoxide dismutase 3, extracellular (SOD3) | 5 | 1 | Sepsis; pneumonia | Eur | 3,5 |
Toll-like receptor 1 (TLR1) | 14 | 12 | Sepsis | Eur, Afr | 37 |
Tumor necrosis factor alpha (TNF) | 3 | 3 | Mixed ICU | Eur | 3,5 |
Tumor necrosis factor beta, lymphotoxin alpha (LTA) | 4 | 4 | Mixed ICU | Eur | 3,5 |
Vascular endothelial growth factor (VEGFA) | 10 | 8 | Mixed ICU | Eur | 3,5,41 |
Genes not covered by IBC platform | Â | Â | Â | Â | |
Ferritin light polypeptide (FTL) | -- | -- | Mixed ICU | Eur | 3,5 |
Heme oxygenase 2 (HMOX2) | -- | -- | Mixed ICU | Eur | 3,5 |
Peptidase inhibitor 3, elafin (PI3) | -- | -- | Mixed ICU | Eur | 5 |
Surfactant protein B (SFTPB) | -- | -- | Pneumonia, mixed ICU | Multi | 3,5 |