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Table 2 Candidate Gene list

From: SNP-set analysis replicates acute lung injury genetic risk factors

Candidate Gene (gene symbol)

# SNPs AA

# SNPs EA

ALI Risk Factor

Ancestry

Ref

Angiotensin converting enzyme (ACE)

39

24

Mixed ICU

Eur

3,5

Angiopoietin-2 (ANGPT2)

63

52

Trauma

Afr, Eur

13, 35

Chemokine (CXC motif) ligand 2 (CXCL2)

5

4

Sepsis

Eur

3,5

Epidermal growth factor (EGF)

36

20

Mixed ICU; Sepsis

Eur

34

Factor V (F5)

84

77

Mixed ICU

Eur

3,5

FAS (FAS, TNF receptor superfamily, member 6)

27

18

Mixed ICU; SIRS

Eur

16

Interleukin-6 (IL6)

15

10

Mixed ICU; sepsis

Eur

3,5,40

Interleukin-8 (IL8)

9

7

Trauma

Eur

3,5

Interleukin-10 (IL10)

5

9

Mixed ICU; trauma

Eur

3,5,38

Interleukin-1 receptor associated kinase 3 (IRAK3)

25

22

Sepsis

Eur

14

Mannose binding lectin (MBL2)

7

9

Mixed ICU

Eur, Chi

3,5

Macrophage migration inhibitory factor (MIF)

1

1

Sepsis

Eur, Afr

3,5

Myosin light chain kinase (MYLK)

10

8

Sepsis; trauma

Eur, Afr

3,5

NAD(P)H dehydrogenase, quinone 1 (NQO1)

14

11

Trauma

Eur

3

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1)

57

54

Mixed ICU

Eur

3,5

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)

14

18

Mixed ICU

Eur

3,5,39

Nuclear factor (erythroid-derived 2-like) 2 (NFE2L2)

19

16

Trauma

Eur

3,5

Pre-B-cell colony enhancing factor (PBEF1)

7

5

Sepsis; mixed ICU

Eur

3,5

Plasminogen activator, urokinase (PLAU)

2

2

Sepsis; pneumonia

Eur

3,5

Plasminogen activator inhibitor type 1 (SERPINE1)

14

8

Pneumonia

Multi

15

Superoxide dismutase 3, extracellular (SOD3)

5

1

Sepsis; pneumonia

Eur

3,5

Toll-like receptor 1 (TLR1)

14

12

Sepsis

Eur, Afr

37

Tumor necrosis factor alpha (TNF)

3

3

Mixed ICU

Eur

3,5

Tumor necrosis factor beta, lymphotoxin alpha (LTA)

4

4

Mixed ICU

Eur

3,5

Vascular endothelial growth factor (VEGFA)

10

8

Mixed ICU

Eur

3,5,41

Genes not covered by IBC platform

    

Ferritin light polypeptide (FTL)

--

--

Mixed ICU

Eur

3,5

Heme oxygenase 2 (HMOX2)

--

--

Mixed ICU

Eur

3,5

Peptidase inhibitor 3, elafin (PI3)

--

--

Mixed ICU

Eur

5

Surfactant protein B (SFTPB)

--

--

Pneumonia, mixed ICU

Multi

3,5