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Table 3 Results of the Association Test for ESR1 Haplotypes between ASC and HBV-related ALF Groups

From: Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population

Characteristic

AsC

HBV-ALF

P value

OR (95%CI)

(2n = 1714)

(2n = 690)

Haplotype, no. (%)

[T; T]

1023(59.7)

365(50.8)

  

[T; C]

142(8.3)

82(11.5)

  

[C; T]

54(3.1)

36(5.0)

  

[C; C]

495(28.9)

235(32.7)

  

Total (3df) §

  

0.0002

 

Haplotype groups, no. (%)

[T; T]/[T; T]

294(34.3)

97(27.1)

  

[T; T]/[-;-]

435(50.8)

171(47.6)

  

[-;-]/[-;-]

128(14.9)

91(25.3)

0.0004

1.53(1.23 ~ 1.96)

  1. Notes: §For haplotype, P values were given by 2 × 4 table chi-square; ‘[-;-]’ means any other haplotypes; OR = odds ratio; CI = confidence interval; the association was analyzed by logistic regression analysis with adjustment for covariates, including age, sex, and alcohol consumption. AsC, asymptomatic carriers;HBV- ALF, patients with HBV-related acute liver failure.