Skip to main content

Advertisement

Table 2 Stratification Analysis of Age and Gender on Association between ESR1 c.30 T > C & c.453-397 T > C Genotypes and Different Groups

From: Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population

  c.453-397 T > C c.30 T > C
AsC HBV-ALF P value OR (95%CI) AsC HBV-ALF P value OR (95%CI)
Men only. n = 510 n = 298    n = 510 n = 298   
TT 193(37.8) 94(31.5)    233(457) 121(40.6)   
TC 263(51.6) 149(50.0)    230(45.1) 131(43.9)   
CC 54(10.6) 55(18.5) 0.003 1.39(1.12-1.73) 47(9.2) 46(15.4) 0.026 1.47(1.06-2.17)
T allele 649(63.6) 337(56.5)    696(68.2) 373(62.6)   
C allele 371(36.4) 259(43.5) 0.005   324(31.8) 223(37.4) 0.022  
Women only n = 347 n = 61    n = 347 n = 61   
TT 137(39.5) 15(24.6)    185(53.3) 22(36.1)   
TC 161(46.4) 33(54.1)    118(34.0) 29(47.5)   
CC 49(14.1) 13(21.3) 0.022 1.56(1.08-2.35) 44(12.7) 10(16.4) 0.037 1.63(1.07-2.47)
T allele 435(62.7) 63(51.6)    488(70.3) 73(59.8)   
C allele 259(37.3) 59(48.4) 0.021   206(29.7) 49(40.2) 0.021  
Age ≥ 40 y n = 277 n = 166    n = 277 n = 166   
TT 118(42.6) 54(32.5)    151(54.5) 71(42.8)   
TC 135(48.7) 83(50.0)    101(36.5) 74(44.6)   
CC 24(8.7) 29(17.5) 0.008 1.83(1.21-2.63) 25(9.02) 21(12.7) 0.041 1.62(1.08-2.54)
T allele 371(67.0) 191(57.5)    403(72.7) 216(65.1)   
C allele 183(33.0) 141(42.5) 0.005   151(27.3) 116(34.9) 0.0003  
Age < 40 y n = 580 n = 193    n = 580 n = 193   
TT 212(36.6) 55(28.5)    267(46.0) 72(37.3)   
TC 289(49.8) 99(51.3)    247(42.6) 86(44.6)   
CC 79(13.6) 39(20.2) 0.036 1.35(1.09-2.21) 66(11.4) 35(18.1) 0.024 1.54(1.07-1.98)
T allele 713(61.5) 209(54.1)    781(68.2) 230(59.6)   
C allele 447(38.5) 177(45.9) 0.011   369(31.8) 156(40.4) 0.003  
  1. Notes: P values were given for the comparison of the allele effect between ASC and HBV-ALF groups by χ 2 tests. Odds ratios (OR) and their 95% confidence interval (95%CI) were given for the comparison of the genotype effect between ASC and HBV-ALF groups by logistic regression analysis with adjustment for covariates, including age, sex, HBeAg status and alcohol consumption. ASC, asymptomatic HBV carriers; HBV- ALF, patients with HBV-related acute liver failure.