Table 2 Stratification Analysis of Age and Gender on Association between ESR1 c.30 T > C & c.453-397 T > C Genotypes and Different Groups

Men only.

n = 510

n = 298

n = 510

n = 298

TT

193(37.8)

94(31.5)

233(457)

121(40.6)

TC

263(51.6)

149(50.0)

230(45.1)

131(43.9)

CC

54(10.6)

55(18.5)

0.003

1.39(1.12-1.73)

47(9.2)

46(15.4)

0.026

1.47(1.06-2.17)

T allele

649(63.6)

337(56.5)

696(68.2)

373(62.6)

C allele

371(36.4)

259(43.5)

0.005

324(31.8)

223(37.4)

0.022

Women only

n = 347

n = 61

n = 347

n = 61

TT

137(39.5)

15(24.6)

185(53.3)

22(36.1)

TC

161(46.4)

33(54.1)

118(34.0)

29(47.5)

CC

49(14.1)

13(21.3)

0.022

1.56(1.08-2.35)

44(12.7)

10(16.4)

0.037

1.63(1.07-2.47)

T allele

435(62.7)

63(51.6)

488(70.3)

73(59.8)

C allele

259(37.3)

59(48.4)

0.021

206(29.7)

49(40.2)

0.021

Age ≥ 40 y

n = 277

n = 166

n = 277

n = 166

TT

118(42.6)

54(32.5)

151(54.5)

71(42.8)

TC

135(48.7)

83(50.0)

101(36.5)

74(44.6)

CC

24(8.7)

29(17.5)

0.008

1.83(1.21-2.63)

25(9.02)

21(12.7)

0.041

1.62(1.08-2.54)

T allele

371(67.0)

191(57.5)

403(72.7)

216(65.1)

C allele

183(33.0)

141(42.5)

0.005

151(27.3)

116(34.9)

0.0003

Age < 40 y

n = 580

n = 193

n = 580

n = 193

TT

212(36.6)

55(28.5)

267(46.0)

72(37.3)

TC

289(49.8)

99(51.3)

247(42.6)

86(44.6)

CC

79(13.6)

39(20.2)

0.036

1.35(1.09-2.21)

66(11.4)

35(18.1)

0.024

1.54(1.07-1.98)

T allele

713(61.5)

209(54.1)

781(68.2)

230(59.6)

C allele

447(38.5)

177(45.9)

0.011

369(31.8)

156(40.4)

0.003