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Table 5 Risk of chemotherapy resistance in breast cancer patients with different CYP2C9*2 genotypes and tumour characteristics
| Group | Allele/ Genotype CYP2C9*2 C430T | Positive neoadjuvant chemotherapy response | Negative neoadjuvant chemotherapy response | OR | CI (95%) | p | ||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| Cancer hereditary load | C | 167 | 91.76 | 7 | 70.00 | 4.77 | 0.71 - 23.47 | 0.055 |
| T | 15 | 8.24 | 3 | 30.00 | ||||
| CC | 76 | 83.52 | 2 | 40.00 | 0.13 | 0.01 - 1.29 | 0.04 | |
| CT | 15 | 16.48 | 3 | 60.00 | 7.60 | 0.78 - 95.24 | 0.04 | |
| TT | 0 | 0.00 | 0 | 0.00 | * | |||
| Nodal form | C | 371 | 91.83 | 10 | 71.43 | 4.50 | 0.97 - 16.60 | 0.027 |
| T | 33 | 8.17 | 4 | 28.57 | ||||
| CC | 169 | 83.66 | 3 | 42.86 | 0.15 | 0.02 - 0.92 | 0.019 | |
| CT | 33 | 16.34 | 4 | 57.14 | 6.83 | 1.09 - 48.12 | 0.019 | |
| TT | 0 | 0.00 | 0 | 0.00 | * | |||
| Cancer hereditary load + nodal form | C | 136 | 91.89 | 3 | 50.00 | 11.33 | 1.32 - 91.23 | 0.01 |
| T | 12 | 8.11 | 3 | 50.00 | ||||
| CC | 62 | 83.78 | 0 | 0.00 | 0.06 | 0.01 - 0.91 | 0.02 | |
| CT | 12 | 16.22 | 3 | 100.00 | 15.50 | 1.08 - 826.12 | 0.02 | |
| TT | 0 | 0.00 | 0 | 0.00 | * | |||
