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Table 1 List of predicted miRNAs binding to a conserved region of human ADAM10 3'UTR

From: Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10

miRNA

∅ kcal/mol

Confirmations

Differential regulated in AD

Conservation zebra fish

1306

−26.85

predicted by 3 programs, mouse ADAM10

 

+

107

−24.24

targets BACE1, predicted by TargetScan, literature for AD, mouse ADAM10

  

103

−25.78

predicted by TargetScan, literature for AD, mouse ADAM10

hippocampus, cerebellum

 

330-5p

−27.20

predicted by microRNA, mouse ADAM10

hippocampus

+

432

−22.81

predicted by microRNA

cerebellum

+

423-5p

−22.1

mouse ADAM10

hippocampus, medial frontal gyrus

 

671-5p

−27.61

mouse ADAM10

 

+

922

−27.99

predicted by microRNA

  

503

−25.41

predicted by microRNA, mouse ADAM10

  

202

−25.33

predicted by microRNA, mouse ADAM10

  

184

−23.33

mouse ADAM10

  
  1. The best eleven predicted miRNAs, which bind to a conserved region of human ADAM10 3'UTR, are shown with additional information like the average predicted binding energy in kcal/mol (column 2), verifications of the miRNAs from literature, by additional mouse ADAM10 prediction or other prediction programs (column 3), the regulation of miRNAs in AD according to Cogswell et al. (column 4) and the conservation of the binding region in zebra fish marked with + in the last column.