Mortality at 13.5 years | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
with 0, 1, or 2 Risk Allele | |||||||||||
Race-ethnicity | SNPs | N | 0 | 1 | 2 | SNP per-risk alelle increase in mortality (OR) (95% CI) | p-value1 | mortality events | Age and race standardized weighted mortality (%) per 1000 person-years (95% CI) | 11 SNP Genotype Score per-risk alelle increase in mortality (OR) (95% CI) | p-value3 |
143 | 12.8 (11.0–14.6) | 1.07 (0.99–1.16) | 0.09 | ||||||||
Non-Hispanic White | rs2022003 | 1,226 | 52.8 | 39.1 | 8.1 | 1.12 (0.81–1.55) | 0.48 | ||||
rs552976 | 1,192 | 9.9 | 41.5 | 48.6 | 0.93 (0.68–1.27) | 0.68 | |||||
rs1800562 | 1,204 | 0.1 | 8.0 | 91.9 | 1.07 (0.45–2.55) | 0.88 | |||||
rs1799884 | 1,207 | 69.2 | 27.6 | 3.3 | 0.98 (0.68–1.40) | 0.90 | |||||
rs4737009 | 1,183 | 57.7 | 35.1 | 7.2 | 0.97 (0.65–1.47) | 0.91 | |||||
rs6474359 | 1,174 | 0.1 | 6.8 | 93.1 | 0.91 (0.48–1.69) | 0.76 | |||||
rs16926246 | 1,206 | 2.5 | 20.7 | 76.8 | 1.34 (0.88–2.05) | 0.17 | |||||
rs10830956 | 1,173 | 49.3 | 42.9 | 7.9 | 1.14 (0.79–1.65) | 0.48 | |||||
rs282606 | 1,183 | 74.4 | 22.9 | 2.7 | 0.85 (0.58–1.22) | 0.37 | |||||
rs1046896 | 1,205 | 47.4 | 42.9 | 9.7 | 1.11 (0.80–1.54) | 0.52 | |||||
rs855791 | 1,183 | 33.2 | 48.3 | 18.5 | 1.14 (0.81–1.62) | 0.45 | |||||
100 | 19.4 (15.8–22.9) | 1.04(0.95–1.14) | 0.39 | ||||||||
Non-Hispanic Black | rs2022003 | 869 | 55.2 | 39.2 | 5.6 | 1.40 (0.97–2.04) | 0.07 | ||||
rs552976 | 882 | 10.2 | 42.8 | 47.0 | 0.96 (0.67–1.39) | 0.84 | |||||
rs1800562 | 887 | 0.1 | 7.1 | 92.8 | 2.81 (1.11–7.13) | 0.03 | |||||
rs1799884 | 888 | 68.7 | 28.2 | 3.1 | 0.96 (0.65–1.43) | 0.86 | |||||
rs4737009 | 861 | 19.0 | 51.7 | 29.3 | 1.11 (0.77–1.59) | 0.57 | |||||
rs6474359 | 853 | 6.4 | 38.6 | 55.1 | 0.73 (0.51–1.03) | 0.08 | |||||
rs16926246 | 885 | 1.6 | 19.7 | 78.7 | 1.13 (0.66–1.92) | 0.66 | |||||
rs10830956 | 832 | 37.7 | 47.0 | 15.3 | 1.18 (0.84–1.67) | 0.34 | |||||
rs282606 | 859 | 20.2 | 50.8 | 29.1 | 0.93 (0.68–1.27) | 0.63 | |||||
rs1046896 | 888 | 50.2 | 40.9 | 8.9 | 1.17 (0.85–1.63) | 0.33 | |||||
rs855791 | 857 | 70.2 | 25.6 | 4.2 | 0.93 (0.63–1.38) | 0.73 | |||||
55 | 14.5 (12.0–16.9) | 1.03 (0.90–1.18) | 0.71 | ||||||||
Mexican American | rs2022003 | 896 | 41.9 | 45.6 | 12.5 | 0.96 (0.64–1.44) | 0.84 | ||||
rs552976 | 890 | 13.6 | 41.5 | 44.8 | 0.99 (0.67–1.46) | 0.97 | |||||
rs1800562 | 904 | 0.1 | 4.8 | 95.1 | 1.30 (0.44–3.85) | 0.63 | |||||
rs1799884 | 904 | 68.7 | 27.3 | 4.0 | 0.85 (0.54–1.36) | 0.50 | |||||
rs4737009 | 884 | 57.6 | 37.1 | 5.2 | 1.33 (0.88–2.02) | 0.18 | |||||
rs6474359 | 883 | 0.2 | 6.8 | 93.0 | 0.85 (0.35–2.03) | 0.71 | |||||
rs16926246 | 904 | 1.3 | 19.4 | 79.3 | 2.04 (1.02–4.08) | 0.04 | |||||
rs10830956 | 874 | 59.7 | 33.8 | 6.5 | 0.90 (0.57–1.40) | 0.64 | |||||
rs282606 | 882 | 67.6 | 28.4 | 4.0 | 0.68 (0.41–1.12) | 0.13 | |||||
rs1046896 | 904 | 47.3 | 43.6 | 9.2 | 1.06 (0.70–1.60) | 0.78 | |||||
rs855791 | 878 | 30.2 | 50.7 | 19.2 | 0.95 (0.64–1.40) | 0.80 |