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Table 4 Association of 11 SNPs and the Genotype Score with mortality by race-ethnicity, Third National Health and Nutrition Examination Survey (NHANES III)

From: Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)

   

Mortality at 13.5 years

      
   

with 0, 1, or 2 Risk Allele

      

Race-ethnicity

SNPs

N

0

1

2

SNP per-risk alelle increase in mortality (OR) (95% CI)

p-value1

mortality events

Age and race standardized weighted mortality (%) per 1000 person-years (95% CI)

11 SNP Genotype Score per-risk alelle increase in mortality (OR) (95% CI)

p-value3

        

143

12.8 (11.0–14.6)

1.07 (0.99–1.16)

0.09

Non-Hispanic White

rs2022003

1,226

52.8

39.1

8.1

1.12 (0.81–1.55)

0.48

    
 

rs552976

1,192

9.9

41.5

48.6

0.93 (0.68–1.27)

0.68

    
 

rs1800562

1,204

0.1

8.0

91.9

1.07 (0.45–2.55)

0.88

    
 

rs1799884

1,207

69.2

27.6

3.3

0.98 (0.68–1.40)

0.90

    
 

rs4737009

1,183

57.7

35.1

7.2

0.97 (0.65–1.47)

0.91

    
 

rs6474359

1,174

0.1

6.8

93.1

0.91 (0.48–1.69)

0.76

    
 

rs16926246

1,206

2.5

20.7

76.8

1.34 (0.88–2.05)

0.17

    
 

rs10830956

1,173

49.3

42.9

7.9

1.14 (0.79–1.65)

0.48

    
 

rs282606

1,183

74.4

22.9

2.7

0.85 (0.58–1.22)

0.37

    
 

rs1046896

1,205

47.4

42.9

9.7

1.11 (0.80–1.54)

0.52

    
 

rs855791

1,183

33.2

48.3

18.5

1.14 (0.81–1.62)

0.45

    
        

100

19.4 (15.8–22.9)

1.04(0.95–1.14)

0.39

Non-Hispanic Black

rs2022003

869

55.2

39.2

5.6

1.40 (0.97–2.04)

0.07

    
 

rs552976

882

10.2

42.8

47.0

0.96 (0.67–1.39)

0.84

    
 

rs1800562

887

0.1

7.1

92.8

2.81 (1.11–7.13)

0.03

    
 

rs1799884

888

68.7

28.2

3.1

0.96 (0.65–1.43)

0.86

    
 

rs4737009

861

19.0

51.7

29.3

1.11 (0.77–1.59)

0.57

    
 

rs6474359

853

6.4

38.6

55.1

0.73 (0.51–1.03)

0.08

    
 

rs16926246

885

1.6

19.7

78.7

1.13 (0.66–1.92)

0.66

    
 

rs10830956

832

37.7

47.0

15.3

1.18 (0.84–1.67)

0.34

    
 

rs282606

859

20.2

50.8

29.1

0.93 (0.68–1.27)

0.63

    
 

rs1046896

888

50.2

40.9

8.9

1.17 (0.85–1.63)

0.33

    
 

rs855791

857

70.2

25.6

4.2

0.93 (0.63–1.38)

0.73

    
        

55

14.5 (12.0–16.9)

1.03 (0.90–1.18)

0.71

Mexican American

rs2022003

896

41.9

45.6

12.5

0.96 (0.64–1.44)

0.84

    
 

rs552976

890

13.6

41.5

44.8

0.99 (0.67–1.46)

0.97

    
 

rs1800562

904

0.1

4.8

95.1

1.30 (0.44–3.85)

0.63

    
 

rs1799884

904

68.7

27.3

4.0

0.85 (0.54–1.36)

0.50

    
 

rs4737009

884

57.6

37.1

5.2

1.33 (0.88–2.02)

0.18

    
 

rs6474359

883

0.2

6.8

93.0

0.85 (0.35–2.03)

0.71

    
 

rs16926246

904

1.3

19.4

79.3

2.04 (1.02–4.08)

0.04

    
 

rs10830956

874

59.7

33.8

6.5

0.90 (0.57–1.40)

0.64

    
 

rs282606

882

67.6

28.4

4.0

0.68 (0.41–1.12)

0.13

    
 

rs1046896

904

47.3

43.6

9.2

1.06 (0.70–1.60)

0.78

    
 

rs855791

878

30.2

50.7

19.2

0.95 (0.64–1.40)

0.80

    
  1. SNP: single nucleaotide polymorphism; OR: odds ratio; CI: confidence interval.
  2. 1. p-value associated with the OR for the per-risk allele increase in mortality for each SNP.
  3. 2. p=<.0001 for the global difference in mortality across race-ethnic groups.
  4. 3. p-value associated with the OR for the per-risk allele increase in mortality for the genotype risk score.