Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)

Table 2 Regression coefficients of 11 HbA _1c -associated SNPs on HbA _1c levels by race-ethnicity, Third National Health and Nutrition Examination Survey (NHANES III)

			Non-Hispanic White		Non-Hispanic Black		Mexican American		p-value for heterogeneity³
SNPs	Chr.	Nearest Gene	β¹(SE)	p-value²	β¹(SE)	p-value²	β¹(SE)	p-value²
rs2022003	1	SPTA1	0.021 (0.02)	0.34	0.024 (0.03)	0.48	0.038 (0.02)	0.09	0.75
rs552976	2	ABCB11/G6PC2	0.030 (0.02)	0.13	0.015 (0.03)	0.64	0.011 (0.02)	0.62	0.76
rs1800562	6	HFE	0.022 (0.06)	0.73	0.1041 (0.07)	0.14	0.005 (0.10)	0.96	0.27
rs1799884	7	GCK	-0.003 (0.03)	0.91	-0.031 (0.04)	0.40	0.041 (0.03)	0.13	0.78
rs4737009	8	ANK1	0.047 (0.02)	0.03	0.038 (0.03)	0.20	0.052 (0.03)	0.06	0.99
rs6474359	8	ANK1	0.1024 (0.05)	0.03	0.026 (0.04)	0.49	-0.002 (0.06)	0.97	0.41
rs16926246	10	HK1	-0.050 (0.03)	0.08	0.036 (0.04)	0.37	-0.005 (0.03)	0.87	0.71
rs10830956	11	MTNR1B	-0.010 (0.02)	0.62	-0.011 (0.03)	0.74	0.030 (0.03)	0.24	0.38
rs282606	13	ATP11A /	0.037 (0.03)	0.17	0.019 (0.03)	0.53	-0.015 (0.03)	0.60	0.90
rs1046896	17	FN3K	0.014 (0.02)	0.47	-0.034 (0.03)	0.24	-0.021 (0.02)	0.35	0.23
rs855791	22	TMPRSS6	0.048 (0.02)	0.01	0.025 (0.04)	0.49	0.050 (0.02)	0.02	0.52

SE: standard error; Chr.: chromosome.
1. β-coefficients (SE) (change in HbA_1c per SNP risk allele) of linear regression models adjusted for age and sex.
2. p-values for β-coefficients based on Satterthwaite adjusted-F test.
3. p-values for difference in β-coefficients acris race-ethnic groups.

ISSN: 1471-2350