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Figure 2 | BMC Medical Genetics

Figure 2

From: Beta catenin and cytokine pathway dysregulation in patients with manifestations of the "PTEN hamartoma tumor syndrome"

Figure 2

Molecular alterations of PI3K/Akt and WNT pathways associated with PHTS syndrome. a) Western blot assay of β-catenin protein. H1-5, H6-10, H11-15, H15-20: mixes of healthy subjects. PHTS1, PHTS2 and PHTS3: patients affected by PHTS syndrome, as reported in Table 1. b) Real Time PCR quantification analysis of COX2, CCND1, cMYC, and APC messengers. H 1-5, H6-10, H11-15, H15-20: mixes of healthy subjects; Hm: mean value between all healthy samples used as calibrator to measure the relative expression; PHTS1, PHTS2 and PHTS3: patients affected by PHTS syndrome, as reported in Table 1.

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