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Figure 2 | BMC Medical Genetics

Figure 2

From: Systems analysis of inflammatory bowel disease based on comprehensive gene information

Figure 2

Protein-protein interactions among the genes with high functional similarities to the drug targets. (A) A network composed of functionally similar genes to prostaglandin G/H synthetase 1 and 2, arachidonate 5-lipoxygenase, and PPARG, all of which are drug targets for IBDmild. (B) A network composed of functionally similar genes to TNF receptor 1A and 1B, which are drug targets for IBDsevere. In each network, a triangle node indicates a gene common to the HDNs of IBDmild and IBDsevere, a circle node indicates a gene specific either the HDN of IBDmild or IBDsevere. A node bordered with an orange line indicates a gene detected by GWAS. An edge connecting the GWAS genes is also highlighted in pale orange. A node marked with an arrow indicates a differentially expressed gene in GSE6731. A blue arrow indicates an up-regulated gene in IBMmild, while a red arrow indicates an up-regulated gene in IBMsevere. Both networks are divided into three portions by colored areas. The blue area indicates genes relate to tissue remodeling. The green area indicates genes relate to inflammation and immunoregulation. The rose area indicates genes relate to tumorigenesis and apoptosis.

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