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Figure 4 | BMC Medical Genetics

Figure 4

From: Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation

Figure 4

Frequency dependence of conduction. Three different voltage protocols were applied (60 bpm (+20 mV for 200 ms, followed by 800 ms at -80 mV); 120 bpm (+20 mV for 180 ms, followed by 320 ms at -80 mV); 180 bpm (+20 mV for 150 ms, followed by 180 ms at -80 mV)). The bar graph summarizes the amount of charge conducted by KV7.1-WT/KCNE1 (black; n = 10) or KV7.1/KCNE1-G60D (white; n = 15) channels in the first 130 ms after the capacitive spike (10 ms) of the pulse at the 7th second when normalized to the charge carried at 60 bpm. Representative current traces recorded (left: KV7.1/KCNE1; right: KV7.1/KCNE1-G60D) using the 60 bpm (black) and 120 bpm (gray) protocols are shown on the right.

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