Table 3 Distribution of cGRS, wGRS, and demographic characteristic of case patients and control subjects
From: Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model
Variable | Case no. (%) | Control no. (%) | Logistic regression†OR (95% CI) | Pfor trend | ROC AUC/c statistic |
|---|---|---|---|---|---|
(95% CI) (BOC) | |||||
cGRS (count risk allele) | |||||
0-1 | 125 (5.48) | 226 (8.11) | 1.00 (ref.) | <0.001 | 0.542 (0.525-0.557)‡ |
2 | 337 (14.76) | 465 (15.70) | 1.31 (1.01-1.70) | (0.540)* | |
3 | 589 (25.80) | 733 (26.32) | 1.45 (1.14-1.85) | ||
4 | 600 (26.28) | 740 (26,57) | 1.47 (1.15-1.87) | ||
5 | 435 (19.05) | 453 (16.27) | 1.74 (1.35-2.34) | ||
≧6 | 197 (8.63) | 168 (6.03) | 2.12 (1.57-2.86) | ||
wGRS (weighted genetic risk score) | |||||
0 (<Q10) | 222 (9.72) | 400 (14.36) | 1.00 (ref.) | <0.001 | 0.551 (0.532-0.564)‖ |
1 (Q10-Q20) | 192 (8.41) | 241 (8.65) | 1.44 (1.12-1.84) | (0.550)* | |
2 (Q20-Q30) | 211 (9.24) | 272 (9.77) | 1.40 (1.10-1.78) | ||
3 (Q30-Q40) | 215 (9.42) | 299 (10.74) | 1.30 (1.02-1.65) | ||
4 (Q40-Q50) | 423 (18.53) | 512 (18.38) | 1.49 (1.21-1.83) | ||
5 (Q50-Q60) | 102 (4.47) | 115 (4.13) | 1.60 (1.17-2.19) | ||
6 (Q60-Q70) | 140 (6.13) | 173 (6.21) | 1.46 (1.11-1.92) | ||
7 (Q70-Q80) | 185 (8.10) | 195 (7.00) | 1.71 (1.38-2.22) | ||
8 (Q80-Q90)) | 309 (13.53) | 323 (11.60) | 1.72 (1.38-2.16) | ||
9 (≧Q90)) | 284 (12.44) | 255 (9.16) | 2.01 (1.59-2.54) | ||
Age (mean±SD) | 60.09±10.29 | 60.56±9.58 | |||
Age group | |||||
1 (≦60 year) | 1113 (48.75) | 1360 (48.53) | 1.00 (ref.) | 0.954 | - |
2(>60 year) | 1170 (51.25) | 1425 (51.17) | 1.00 (0.90-1.12) | ||
Gender | |||||
Male | 1683 (73.72) | 2039 (73.21) | 1.00 (ref.) | 0.686 | - |
Female | 600 (26.28) | 746 (26.79) | 0.97 (0.86-1.11) | ||
Smoking status | |||||
Never | 801 (35.09) | 1517 (54.47) | 1.00 (ref.) | <0.001 | 0.619 (0.603-0.634)※ |
Light-smokers | 416 (18.22) | 542 (19.46) | 1.45 (1.25-1.70) | (0.618)* | |
Heavy-smokers | 1066 (46.69) | 726 (26.07) | 2.78 (2.45-3.16) |