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Table 2 Genetic variants identified in the promoter regions of the IL2R alpha (CD25) gene locus

From: In-vitro characterization of novel and functional regulatory SNPs in the promoter region of IL2 and IL2R alpha in a Gabonese population

SNP (rs#)

Position

Polym orphism

Flanking sequences

Genotype

Analysed individuals

Allele

Frequencya

Frequencies (Hapmap YRI, CEU, CHB)b

rs12722617

−398

C>T

TTCGC[C/T] GCATC

CC

35

C

0.875

0.932, 1.000, NA

CT

5

T

0.125

0.068, 0.000, NA

ss410961577

−409

C>T

GGATC[C/T] TTCAG

CC

38

C

0.950

NA

CT

2

T

0.050

rs12722616

−516

C>T

AACAC [C/T] TTATA

CC

35

C

0.875

0.924, 1.000, 1.000

    

CT

5

T

0.125

0.076, 0.000, 0.000

  1. aFrequency corresponds for both allele and genotypes; b: YRI: Yoruba population representing Sub- Saharan African individual group, CEU: European, CHB: Han Chinese; NA: data not available.