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Table 3 The genotype frequency of stratified by gender among Graves’ disease patients in Taiwan

From: Thymic stromal lymphopoietin gene promoter polymorphisms and expression levels in Graves’ disease and Graves’ ophthalmopathy

SNP ID with GO w/o GO Pvaluea OR (95% CI)
N (%) N (%)
rs3806933     
Female     
C/C 64 (42.7) 119 (53.1)   1
C/T 77 (51.3) 80 (35.7)   1.79 (1.16, 2.77)
T/T 9 (6) 25 (11.2) 0.007 (genotype) 0.67 (0.29, 1.52)
 C/T + T/T 86 (57.3) 105 (46.9) 0.047 (dominant) 1.52 (1.00, 2.31)
C allele 205 (68.3) 318 (71.0)   1
T allele 95 (31.7) 130 (29.0) 0.44 1.13 (0.83, 1.56)
Male     
C/C 19 (37.3) 21 (46.7)   1
C/T 24 (47.1) 22 (48.9)   1.21 (0.52, 2.82)
T/T 8 (15.7) 2 (4.4) 0.18 (genotype) 4.42 (0.83, 23.47)
 C/T + T/T 32 (62.7) 24 (53.3) 0.35 (dominant) 1.47 (0.65, 3.33)
C allele 62 (60.8) 64 (71.1)   1
T allele 40 (39.2) 26 (28.9) 0.13 1.59 (0.87, 2.91)
rs2289276     
Female     
T/T 2 (1.3) 15 (6.7)   1
C/T 60 (40.0) 75 (33.5)   6.00 (1.32, 27.27)
C/C 88 (58.7) 134 (59.8) 0.034 (genotype) 4.93 (1.10, 22.07)
 C/T + C/C 148 (98.7) 209 (93.3) 0.015 (recessive) 5.31 (1.20, 23.57)
C allele 236 (78.7) 343 (76.6)   1
T allele 64 (21.3) 105 (23.4) 0.50 0.89 (0.62, 1.26)
Male     
T/T 3 (5.9) 4 (8.9)   1
C/T 17 (33.3) 15 (33.3)   1.51 (0.29, 7.87)
C/C 31 (60.8) 26 (57.8) 0.847 (genotype) 1.59 (0.33, 7.76)
 C/T + C/C 48 (94.1) 41 (91.1) 0.572 (recessive) 1.56 (0.33, 7.38)
C allele 79 (77.5) 67 (74.4)   1
T allele 23 (22.5) 23 (25.6) 0.63 0.85 (0.44, 1.65)
rs2289278     
Female     
C/C 80 (53.3) 148 (66.1)   1
C/G 59 (39.3) 66 (29.5)   1.65 (1.06, 2.58)
G/G 11 (7.3) 10 (4.5) 0.042 (genotype) 2.04 (0.83, 5.00)
 C/G + G/G 70 (46.7) 76 (33.9) 0.013 (dominant) 1.70 (1.12, 2.60)
C allele 219 (73.0) 362 (80.8)   1
G allele 81 (27.0) 86 (19.2) 0.012 1.56 (1.10, 2.20)
Male     
C/C 34 (66.7) 29 (64.4)   1
C/G 14 (27.5) 13 (28.9)   0.92 (0.37, 2.27)
G/G 3 (5.9) 3 (6.7) 0.971 (genotype) 0.85 (0.16, 4.55)
 C/G + G/G 17 (33.3) 16 (35.6) 0.819 (dominant) 0.91 (0.39, 2.11)
C allele 82 (80.4) 71 (78.9)   1
G allele 20 (19.6) 19 (21.1) 0.80 0.91 (0.45, 1.84)
  1. Abbreviations: CI, confidence interval; GO, Graves’ ophthalmopathy; SNP, single-nucleotide polymorphism. aDominant or recessive genotype frequencies were determined by chi-square test using 2 × 2 contingency tables. Genotype frequencies were determined by chi-square test using 2 × 3 contingency tables. Compared Graves’ diseases patients with and without GO. P values less than 0.016 were considered significant.