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Table 1 Genotype and allele frequencies of markers for Graves’ disease patients in Taiwan

From: Thymic stromal lymphopoietin gene promoter polymorphisms and expression levels in Graves’ disease and Graves’ ophthalmopathy

SNP ID

GD with GO (201)

GD without GO (269)

GD (470)

Control (78)

P a

P b

OR (95% CI)

N (%)

N (%)

N (%)

N (%)

Genotype

       

rs3806933

       

C/C

83(41.3)

140 (52.0)

223 (47.4)

37 (47.4)

  

1

C/T

101 (50.2)

102 (37.9)

203 (43.2)

31 (39.7)

  

1.67 (1.13, 2.46)

T/T

17 (8.5)

27 (10.0)

44 (9.4)

10 (12.9)

0.028 (genotype)

0.61

1.06 (0.55, 2.06)

 C/T + T/T

118 (58.7)

129 (48.0)

247 (52.6)

41 (52.6)

0.021 (dominant)

1

1.54 (1.07, 2.23)

rs2289276

       

C/C

5 (2.5)

19 (7.1)

24 (5.1)

9 (11.5)

  

1

C/T

77 (38.3)

90 (33.5)

167 (35.5)

29 (37.2)

  

3.25 (1.16, 9.12)

T/T

119 (59.2)

160 (59.5)

279 (59.4)

40 (51.3)

0.065 (genotype)

0.067

2.83 (1.03, 7.79)

 C/T + C/C

196 (97.5)

250 (92.9)

446 (94.9)

69 (88.5)

0.026 (recessive)

0.027

2.98 (1.09, 8.12)

rs2289278

       

C/C

114 (56.7)

177 (65.8)

291 (61.9)

41 (52.6)

  

1

C/G

73 (36.3)

79 (29.4)

152 (32.3)

32 (41.0)

  

1.43 (0.97, 2.13)

G/G

14 (14)

13 (4.8)

27 (5.8)

5 (6.4)

0.125 (genotype)

0.29

1.67 (0.76, 3.69)

 C/G + G/G

87 (50.3)

92 (34.2)

179 (38.1)

37 (47.4)

0.045 (dominant)

0.12

1.47 (1.01, 2.14)

Allele

       

rs3806933

       

C allele

267 (66.4)

382(71.0)

649 (69)

105 (67.3)

  

1

T allele

135 (33.6)

156 (29.0)

291 (31)

51 (32.7)

0.13

0.66

1.24 (0.94, 1.64)

rs2289276

       

T allele

315 (78.4)

410 (76.2)

725 (77.1)

109 (69.9)

  

1

C allele

87 (21.6)

128 (23.8)

215 (22.9)

47 (30.1)

0.44

0.05

0.88 (0.65, 1.21)

rs2289278

       

C allele

301 (74.9)

433 (80.5)

734 (78.1)

114 (73.1)

  

1

G allele

101 (25.1)

105 (19.5)

206 (21.9)

42 (26.9)

0.04

0.17

1.38 (1.01, 1.89)

  1. Abbreviations: CI, confidence interval; GO, Graves’ ophthalmopathy; SNP, single-nucleotide polymorphism. aDifferences in allele, dominant or recessive genotype frequencies were determined by chi-square test using 2 × 2 contingency tables. Differences in genotype frequencies were determined by chi-square test using 2 × 3 contingency tables. Compared Graves’ diseases patients with and without GO. b Compared Graves’ disease patients with normal population. P values less than 0.016 were considered significant.