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Table 2 Serum MMP9 and sE-selectin levels by SELE genotype in recessive model

From: Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level

rs Number and Genotypes

MMP9

Pvalue#

Adjusted

sE-selectin (mg/L)

P value#

P value*

Adjusted

  

(mg/L)

 

Pvalue

   

Pvalue

rs10800469

AA (n = 113)

143.0 ± 107.4

0.929

1

55.0 ± 30.2

0.162

0.060

0.180

 

AG + GG (n =388)

141.9 ± 113.9

  

51.9 ± 24.3

   

rs3917406

GG (n = 122)

159.4 ± 138.9

0.066

0.131

49.0 ± 27.6

0.023

0.005

0.031

 

AA + AG (n = 378)

136.6 ± 102.0

  

53.7 ± 25.1

   

rs5361

AA (n = 487)

142.9 ± 113.4

0.477**

-

52.6 ± 25.7

0.943**

0.865**

-

 

AC (n = 12)

118.1 ± 62.7

  

56.3 ± 31.3

   
 

CC (n = 0)

-

  

-

   

rs3917412

AA (n = 40)

139.4 ± 84.5

0.964

0.963

49.5 ± 19.7

0.624

0.824

0.824

 

AG + GG (n = 459)

142.6 ± 114.7

  

52.9 ± 26.3

   

rs2179172

CC (n = 21)

137.8 ± 100.5

0.872

1

50.1 ± 24.9

0.772

0.492

0.590

 

AA + AC (n = 476)

143.0 ± 113.1

  

52.9 ± 25.9

   

rs3917419

AA (n = 15)

209.5 ± 119.3

0.002

0.005

61.1 ± 47.2

0.326

0.224

0.336

 

AG + GG (n = 485)

139.4 ± 110.9

  

52.4 ± 24.8

   

rs5368

TT (n = 25)

234.0 ± 209.9

1.1 × 10-4

6.9 × 10-4

45.6 ± 14.4

0.354

0.181

0.336

 

CC + CT (n = 476)

137.0 ± 102.5

  

52.6 ± 25.1

   
  1. Continuous variables are presented as mean ± SD. MMP9 and sE-selectin values were logarithmically transformed before statistical testing to meet the assumption of normal distributions; however, the untransformed data are shown.
  2. #Multiple linear regression, adjusted for age, gender, smoking and BMI. *Multiple linear regression, adjusted for age, gender, smoking, BMI, sICAM1 and MMP9 levels. Adjusted P values were computed by the false discovery rate method. **Comparison between AA and AC genotypes.