Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population

Table 2 Association between PNPLA3 I148M and clinical parameters in NAFLD cases and controls ^†

Variable	Cases			P-value^‡	Controls			P-value^‡
	II (n=70)	IM (n=84)	MM (n=49)		II (n=94)	IM (n=90)	MM (n=18)
Age (years)	47.6 ± 13.3	46.9 ± 13.3	45.8 ± 14.3	> 0.10	40.2 ± 12.8	42.7 ± 12.9	46.6 ± 14.7	0.04
BMI (kg/m²)	26.8 ± 4.4	27.1 ± 5.3	26.7 ± 5.3	> 0.10	23.0 ± 3.1	23.8 ± 3.9	24.2 ± 2.9	> 0.10
ALT (IU/L)	32.2 ± 22.5	38.2 ± 28.1	72.2 ± 59.0	1.1×10^-7	17.4 ± 9.2	16.5 ± 7.1	17.5 ± 5.6	> 0.10
AST (IU/L)	28 ± 20.7	30.7 ± 23.8	37.5 ± 40.5	0.07	19.9 ± 4.8	19.7 ± 3.8	19.3 ± 3.6	> 0.10
GGT (IU/L)	73.1 ± 52.1	56.1 ± 58.2	52.8 ± 46.6	> 0.10	25.3 ± 17.1	24.5 ± 16.0	23.4 ± 12.9	> 0.10
Triglycerides (mmol/L)	1.9 ± 1.3	2.2 ± 1.5	2.0 ± 1.4	> 0.10	1.0 ± 0.5	1.1 ± 0.5	1.2 ± 0.4	> 0.10
LDL-C (mmol/L)	3.6 ± 1.2	3.4 ± 0.9	3.0 ± 1.0	4.1×10^-3	2.5 ± 1.1	2.6 ± 1.1	2.8 ± 1.2	> 0.10
HDL-C (mmol/L)	1.3 ± 0.5	1.3 ± 0.7	1.4 ± 0.6	> 0.10	1.9 ± 0.8	1.9 ± 1.0	2.0 ± 1.1	> 0.10
FBG (mmol/L )	6.0 ± 1.1	6.1 ± 1.5	6.0 ± 1.1	> 0.10	5.5 ± 1.3	5.6 ± 1.4	5.9 ± 0.9	> 0.10

^†Data are described by mean ± standard deviation.
^‡Nominal P-values were calculated by fitting linear regression models, in which Age and BMI were adjusted for when testing other variables. After Bonferroni multiple testing correction (18 tests), the only significant association was between ALT levels and genotype in cases (adjusted P-value = 2.0×10^-6).

ISSN: 1471-2350