Table 3 Multivariate linear regressionsa for association between genotypes at the Nrf2 SNPs and decline in FEV1
SNP | Genotype | N | Annual decline in FEV1 Mean ± SD (mL/year) | P value (corrected p value) |
|---|---|---|---|---|
rs2001350 | CC | 43 | 24.7 ± 7.5 | 0.101 |
|  | CT | 296 | 24.2 ± 7.4 |  |
|  | TT | 551 | 23.8 ± 7.9 |  |
rs6726395 | GG | 431 | 26.2 ± 8.3 | 0.0031 (0.016) |
|  | GA | 378 | 22.3 ± 7.4 |  |
|  | AA | 86 | 20.8 ± 8.8 |  |
rs1962142 | AA | 23 | 28.1 ± 10.4 | 0.194 |
|  | AG | 277 | 23.6 ± 6.8 |  |
|  | GG | 591 | 24.0 ± 8.0 |  |
rs2364722 | AA | 157 | 24.9 ± 7.9 | 0.277 |
|  | AG | 421 | 24.0 ± 7.4 |  |
|  | GG | 313 | 23.4 ± 8.1 |  |
rs6721961 | GG | 496 | 23.6 ± 7.8 | 0.900 |
|  | GT | 344 | 24.5 ± 7.7 |  |
|  | TT | 53 | 24.4 ± 7.3 |  |