The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer

BMC Medical Genetics

Table 1 Detection of the mtDNA 4,977 bp deletion in tumor and non-tumor tissues of 104 colorectal cancer patients.

	N	Deletion detected in non-tumor tissues	p-value	OR (95% CI)	Deletion detected in tumor tissues	p-value	OR (95% CI)
Cases	104	13 (12.50%)			17 (16.35%)
Age
≤65	48	7 (14.58%)	0.552	1.423	12 (25.00%)	0.027*	3.400
>65	56	6 (10.71%)		(0.443-4.566)	5 (8.93%)		(1.101-10.495)
BMI#
<18	3	0	0.248	--	0	0.286	--
18-24	65	8 (11.76%)			11 (16.18%)
≥24	25	5 (20.00%)			6 (24.00%)
Differentiation#
Poor	22	2 (9.09%)	0.772	0.590	3 (13.64%)	0.813	0.680
Moderate	69	10 (14.49%)		(0.119-2.924)	13 (18.84%)		(0.175-2.647)
LN metastasis
Positive	43	8 (18.60%)	0.114	2.560	8 (18.60%)	0.601	1.321
Negative	61	5 (8.20%)		(0.775-8.453)	9 (14.75%)		(0.465-3.753)
Stage
I+II	60	5 (8.33%)	0.134	0.409	9 (15.00%)	0.665	0.794
III+IV	44	8 (18.18%)		(0.124-1.350)	8 (18.18%)		(0.280-2.255)

N, case number; BMI, body mass index; Differentiation, tumor cell differentiation status; LN metastasis, lymph node metastasis; Stage, cancer stage classified according to the tumor-node-metastasis (TNM) staging system (American Joint Committee on Cancer); OR, odds ratio; P-values were calculated by chi-square test, * statistically significant; 95% CI, 95% confidence interval; # incomplete data.

ISSN: 1471-2350