Figure 1

A schematic of the SLC11A1 gene region with the T1D genetic association results using a maximum of 5,878 cases and 6,406 controls for the SNPs and 7,700 cases and 7,380 controls for the microsatellite (GT)n. SNPs with P ≤ 0.005 (horizontal dashed line) were chosen to be genotyped in our extended case-control collection (maximum of 8,863 T1D cases and 10,841 controls) and are shown in red. The microsatellite (GT)n is depicted in green. The multiplicative allelic effects model was an appropriate model for all variants (P > 0.05), except for rs1809231 C > G as there was a significant difference between the genotype and the multiplicative allelic effects models (P = 0.019; Table 1). [NCBI build 37 was used]