Figure 1

Change in bilirubin level (between 1 ^st and 2 ^nd bilirubin measurements, mg/dl) by genotype for two UGT1A1 SNPs among neonates who had a repeat bilirubin measured within 33 hours. Figure 1a illustrates the association with SNP rs4148329 - a smaller change is observed for neonates who were homozygous for the mutant allele versus those with wild-type genotypes. This was significant at the P < 0.003 level. A non-significant association with a SNP of comparable minor allele frequency is given in the lower figure (1b) for comparative purposes. In each figure the change in bilirubin for each neonate is given as a diamond; the green lines are the mean values for each genotype and the blue bars show the standard error of the mean.