Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease

BMC Medical Genetics

Table 1 A list of SNPs with significantly higher global F _ST (P < 0.05)

SNPs	Trait	Gene	RAF	Global F _ST	Pvalue	P _cor
rs1378942	Diastolic blood pressure [17]	CSK	0.708 (G)	0.247	0.025	0.022
rs653178	Diastolic blood pressure [17]	ATXN2	0.177 (G)	0.205	0.049	0.031
rs174570	Total, HDL and LDL cholesterol [36]	FADS2	0.730 (C)	0.351	0.002	0.000
rs4796217	Macrophage-mediated inflammation [37]	CCL4L2	0.425 (T)	0.221	0.040	0.032
rs602662*	Folate pathway [22, 38]	FUT2	0.294 (A)	0.240	0.027	0.028
rs9388489	Type 1 diabetes [39]	C6orf97	0.634 (G)	0.308	0.008	0.002
rs3184504*	Type 1 diabetes [39]; diastolic blood pressure and systolic blood pressure[17]	SH2B3	0.179 (T)	0.210	0.045	0.031
rs6499640	BMI and weight[40]	FTO	0.455 (A)	0.208	0.045	0.037

RAF: risk allele frequency; P _cor, P value after correcting for minor allele frequency; CSK, c-src tyrosine kinase; ATXN2, ataxin 2; FADS2, fatty acid desaturase 2; CCL4L2, chemokine (C-C motif) ligand 4-like 2; FUT2, fucosyltransferase 2; C6orf97, chromosome 6 open reading frame 173; SH2B3, SH2B adaptor protein 3; FTO, fat mass and obesity associated
*, non-synonymous SNPs

ISSN: 1471-2350