Single nucleotide polymorphisms at the TRAF1/C5 locus are associated with rheumatoid arthritis in a Han Chinese population

Zhu, Jing; Zhang, Dinging; Wu, Fengxia; He, Fei; Liu, Xiaoqi; Wu, Lijun; Zhou, Bin; Liu, Jianping; Lu, Fang; Liu, Jian; Luo, Ruijun; Long, Wubin; Yang, Minghui; Ma, Shi; Wu, Xiaodan; Shi, Yi; Wu, Tong; Lin, Ying; Yang, Jiyun; Yuan, Guohua; Yang, Zhenglin

doi:10.1186/1471-2350-12-53

Table 3 Association of rs3761847 and rs7021206 in TRAF1/C5 and subgroup RA in a Han Chinese cohort

From: Single nucleotide polymorphisms at the TRAF1/C5 locus are associated with rheumatoid arthritis in a Han Chinese population

SNP	*Group*	HWE	Genotype count and frequency		Allele frequency		Allelic p	OR (95%CI)
			Case (frequency)	Control (frequency)	Case	Control
	anti-CCP positive	Case: 0.76	AA:127 (0.35)	AA:171 ( 0.25)	A: 0.59	A: 0.52	0.0015	1.33 (1.11-1.60)
		Control: 0.058	AG:173 (0.48)	AG:369 ( 0.54)	G: 0.41	G: 0.48
			GG:63 (0.17)	GG:149 ( 0.21)
	anti-CCP negative	Case: 0.81	AA:69 (0.32)	AA:171 ( 0.25)	A: 0.57	A: 0.52	0.040	1.25 (1.01-1.56)
		Control: 0.058	AG:106 (0.50)	AG:369 ( 0.54)	G: 0.43	G: 0.48
rs3761847			GG:38 (0.18)	GG:149 ( 0.21)
	RF positive	Case: 0.81	AA:170 (0.34)	AA:171 ( 0.25)	A: 0.58	A: 0.52	0.0015	1.30 (1.10-1.53)
		Control: 0.058	AG:237 (0.48)	AG:369 ( 0.54)	G: 0.42	G: 0.48
			GG:89 (0.18)	GG:149 ( 0.21)
	RF negative	Case: 0.26	AA:27 (0.34)	AA:171 ( 0.25)	A: 0.61	A: 0.52	0.030	1.44 (1.03-2.01)
		Control: 0.058	AG:43 (0.54)	AG:369 ( 0.54)	G: 0.39	G: 0.48
			GG:10 (0.16)	GG:149 ( 0.21)
	anti-CCP positive	Case: 0.22	AA:139 (0.38 )	AA:343 (0.50 )	G: 0.37	G: 0.29	0.00025	1.42 (1.18-1.72)
		Control: 0.54	AG:180 (0.50 )	AG:291 (0.42 )	A: 0.63	A: 0.71
			GG:44 (0.12 )	GG:55 ( 0.08 )
	anti-CCP negative	Case: 0.18	AA:89 (0.42 )	AA:343 (0.50 )	G: 34	G: 0.29	0.065
		Control: 0.54	AG:104 (0.49 )	AG:291 (0.42 )	A: 0.66	A: 0.71
rs7021206			GG:20 (0.09 )	GG:55 ( 0.08 )
	RF positive	Case: 0.17	AA:193 (0.39 )	AA:343 (0.50 )	G: 0.36	G: 0.29	0.00014	1.40 (1.18-1.67)
		Control: 0.54	AG:244 (0.49 )	AG:291 (0.42 )	A: 0.64	A: 0.71
			GG:59 (0.12 )	GG:55 ( 0.08 )
	RF negative	Case: 0.26	AA:38 (0.48)	AA:343 (0.50 )	G: 0.33	G: 0.29	0.29
		Control: 0.54	AG:31 (0.39)	AG:291 (0.42 )	A: 0.67	A: 0.71
			GG:11 ( 0.13 )	GG:55 ( 0.08 )

SNP: single nucleotide polymorphism, HWE: Hardy-Weinberg equilibrium, OR: odds ratio, CI: confidence interval.

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