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Table 2 Pearson's chi-square test for cases versus controls of SNPs and most frequent hgs

From: Reassessing the role of mitochondrial DNA mutations in autism spectrum disorder

  rCRS ref.a MAb MAFCA c MAFCO c CHI2 Exact P-value Adjusted P-valued OR (95% CI)e
3010G > A G A 0.24 0.27 0.557 0.455 1 0.85 (0.56-1.29)
3915G > A G A 0.02 0.04 0.874 0.350 0.995 0.57 (0.17-1.89)
3992C > T C T 0.00 0.01 1.320 0.251 0.979 -
4216T > C T C 0.13 0.16 0.939 0.333 0.993 0.77 (0.46-1-30)
4336T > C T C 0.04 0.04 0.047 0.828 1 1.11 (0.45-2.72)
4529A > T A T 0.01 0.01 0.182 0.669 1 0.64 (0.08-5.13)
4580G > A G A 0.06 0.03 1.620 0.203 0.941 1.69 (0.75-3.82)
4769A > G A A 0.02 0.02 0.060 0.799 1 1.17 (0.34-4.04)
4793A > C A G 0.00 0.01 1.166 0.280 0.987 -
6776T > C T C 0.04 0.05 0.577 0.448 1 0.69 (0.27-1.79)
7028C > T C C 0.40 0.44 0.683 0.409 0.999 1.16 (0.81-1.67)
10398A > G A G 0.15 0.20 2.010 0.156 0.902 0.70 (0.43-1.15)
10400C > T C T 0.02 0.01 1.023 0.312 0.991 1.97 (0.52-7.52)
10463T > C T C 0.09 0.09 0.001 0.982 1 1.01 (0.53-1.92)
10873T > C T C 0.06 0.04 1.609 0.205 0.951 0.61 (0.28-1.32)
12308A > G A G 0.19 0.23 1.270 0.260 0.982 0.77 (0.49-1.21)
12705C > T C T 0.14 0.08 4.857 0.028 0.315 1.82 (1.06-3.13)
13966A > G A G 0.02 0.02 0.001 0.972 1 1.02 (0.29-3.58)
14766C > T C T 0.47 0.49 0.242 0.622 1 0.91 (0.64-1.31)
H - - 0.40 0.44 0.791 0.374 0.999 0.85 (0.59-1.22)
H1 - - 0.16 0.19 0.689 0.406 0.999 1.22 (0.76-1.96)
HV - - 0.52 0.50 0.121 0.728 1 1.06 (0.75-1.51)
U - - 0.19 0.23 1.248 0.264 0.983 1.29 (0.83-2.01)
J - - 0.03 0.08 4.411 0.036 0.390 2.61 (1.03-6.61)
T - - 0.09 0.08 0.077 0.782 1 0.92 (0.49-1.71)
JT - - 0.12 0.16 1.727 0.189 0.941 1.42 (0.84-2.41)
  1. rCRS = revised Cambridge Reference Sequence; MA = minor allele; MAF = minimum allele frequency.
  2. arCRS: allele in the revised Cambridge Reference Sequence (rCRS)[41];
  3. bMA: minor allele;
  4. cMAF: minimum allele frequency computed on cases (MAFCA) and control (MAFCO) individuals;
  5. dAdjusted P-value: adjustment of chi-square P-values was carried out with a permutation-based approach; number of permutations = 20,000;
  6. eOR (95%CI): ORs were computed with the rCRS allele as a reference