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Figure 3 | BMC Medical Genetics

Figure 3

From: Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism and coronary heart disease

Figure 3

Simulated effects of statin use on the odds ratio for CHD in KIF6 719Arg carriers vs. noncarriers. for varying effects of statin on KIF6 719Arg carriers risk. Results are presented where KIF6 719Arg carriers have 50% increased risk of CHD compared with noncarriers if there is no statin use, and where statin use eliminates 20%, 40%, 60%, 80% and 100% of the excess risk associated with KIF6 719Arg carrier status (Figure 2 assumed 100% of the excess risk was eliminated by statin use). Odds ratios (vertical axis) are presented for increasing percentage of statin use (horizontal axis).

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BMC Medical Genetics

ISSN: 1471-2350

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