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Table 1 Clinical characteristics at onset in type 1 diabetes subjects according to PTPN22 C1858T genotypes

From: The PTPN22C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes

The HSG cohort

C1858T genotype

 

CC

CT

TT

Sex (male/female)

90/96

33/32

3/3

Age (yrs)

9.3 ± 0.3

8.8 ± 0.5

6.7 ± 1.1

Presences of DKA (+/-) (%)

22/78

13/87

17/83

BMI (kg/m2)

17.8 ± 0.2

18.0 ± 0.4

16.3 ± 0.6

HLA risk genes: (Caucasian/Japanese = 253/4)

   

Low (%)

52/0.8 *

46

17

Moderate (%)

11/0.4 *

14

17

High (%)

37/0.4 *

40

67

  1. Data are mean values ± SEM. HLA DRB1 high risk genotypes: DR 03/04 and DR 04/04; HLA DRB1 moderate risk genotypes: DR 03/03 and DR04/08; all other HLA DRB1 genotypes were considered low risk. The HLA DRB1 genotypes for the 4 Japanese patients were: DR 01/09, DR 04/08, DR 09/09 and DR 04/09. These were classified as HLA risk: low, low, moderate and high, respectively* [20].