Variables (n = 164) | Patients with non- pathogenic variants (n = 112) (72.7%) | Patients with pathogenic variants (n = 42) (27.3%) | P value |
---|---|---|---|
A)Demographic characteristics | Â | Â | Â |
Age (year)*a | 46.2(11.4) | 40.3(12.7) | 0.007 |
Sex | 60(53.6) | 21(50.0) | 0.72 |
Female | 52(46.4) | 21(50.0) | Â |
Male | Â | Â | Â |
B) Medical history | Â | Â | Â |
CVD (%)b | 68(60.7) | 37(88.1) | 0.001 |
Age of onset of CVD(%)b ** | 42.7(6.4) | 39.3(9.3) | 0.03 |
Hypertension (%)b | 30(26.8) | 4(9.5) | 0.03 |
Family history of PCVD (%)b | 60(53.6) | 29(69.0) | 0.1 |
Family history of hyperlipidemia (%)b | 59(52.7) | 31(73.8) | 0.03 |
Family history of tendon xanthoma (%)b | 32(28.6) | 16(38.1) | 0.3 |
C) Clinical examination | Â | Â | Â |
BMI | 27.1(4.5) | 28.2(5.5) | 0.25 |
Tendon xanthoma | 35(31.3) | 28(66.7) | <0.001 |
(%)bArcus | 57(50.9) | 20(47.6) | 0.9 |
(%)bXanthelasma (%)b | 24(21.4) | 15(35.7) | 0.09 |
D) Lipid profile parameters a | Â | Â | Â |
TC(mmol/l)* | 7.7(0.9) | 8.3 (1.2) | 0.001 |
TG (mmol/l)* | 1.9(0.8) | 1.7(0.9) | 0.19 |
HDL-C (mmol/l)* | 1.3(0.3) | 1.3(0.4) | 0.96 |
LDL-C (mmol/l)* | 4.9(0.8) | 5.2(1.1) | 0.02 |
TC/HDL-C ratio * | 6.5(2.4) | 6.9(1.9) | 0.23 |