Skip to main content

Advertisement

Table 3 Association between haplotypes and asthma

From: Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population

Gene Chr BP1 BP2 SNP1 SNP2 Haplotype Frequency Odds Ratio Unadjusted p FDR
GSTM1 1 108482748 110031479 rs17672 rs3815029 CCG 0.10 3.01 0.05 0.210
  1 108482748 110031479 rs17672 rs3815029 CGC 0.11 0.36 0.04 0.209
  1 108482748 110031479 rs17672 rs3815029 CGG 0.64 0.82 0.506 0.781
  1 108482748 110031479 rs17672 rs3815029 TCC 0.01 4.48 0.298 0.626
  1 108482748 110031479 rs17672 rs3815029 TGC 0.05 1.58 0.508 0.781
  1 108482748 110031479 rs17672 rs3815029 TGG 0.09 1.18 0.759 0.839
  11 59612059 59622751 rs574700 rs502419 CCACG 0.08 1.63 0.286 0.626
  11 59612059 59622751 rs574700 rs502419 CCTAA 0.07 0.86 0.758 0.839
  11 59612059 59622751 rs574700 rs502419 CCTCA 0.01 1.02 0.982 0.982
MS4A2 11 59612059 59622751 rs574700 rs502419 CCTCG 0.07 0.78 0.595 0.781
  11 59612059 59622751 rs574700 rs502419 CTACG 0.57 1.58 0.114 0.399
  11 59612059 59622751 rs574700 rs502419 TCTAA 0.14 0.43 0.032 0.209
  11 59612059 59622751 rs574700 rs502419 TCTAG 0.04 1.04 0.96 0.982
  11 67106475 67110982 rs6591256 rs947895 AGACC 0.27 1.2 0.519 0.781
  11 67106475 67110982 rs6591256 rs947895 AGATA 0.07 0.28 0.027 0.209
  11 67106475 67110982 rs6591256 rs947895 AGATC 0.01 0.56 0.642 0.793
GSTP1 11 67106475 67110982 rs6591256 rs947895 AGGCC 0.21 2.23 0.018 0.209
  11 67106475 67110982 rs6591256 rs947895 GTACC 0.18 0.82 0.573 0.781
  11 67106475 67110982 rs6591256 rs947895 GTATA 0.02 0.19 0.201 0.603
  11 67106475 67110982 rs6591256 rs947895 GTGCC 0.03 1.59 0.562 0.781
  11 67106475 67110982 rs6591256 rs947895 GTGTA 0.19 0.70 0.288 0.626
  1. † Logistic regression adjusted for sex and performed in PLINK version 1.06. SNP1: SNP of left-most (5') SNP in haplotype, SNP2: SNP of right most (3') SNP in haplotype. ß: Beta estimate, p: p-value. Statistical significance after correction for multiple comparisons evaluated using False Discovery Rate (FDR). FDR ≤ 0.25 denoted statistically significant associations, marked in bold. Models included 129 individuals.