Skip to main content

Table 3 Effects observed for the individual risk alleles and for the combined genetic scores on HbA1c and non-fasting serum glucose levels in 1,486 individuals with type 2 diabetes.

From: Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study)

Individual SNP effects

HbA1c

Non-fasting serum glucose

Gene region

SNP

RAF

Effect size

Std Error

P-value

Sample size

Effect size

Std Error

P-value

Sample size

BNC2

rs10810632

0.09 (C)

0.07

0.11

0.57

1485

-0.00

0.26

0.99

1484

SORCS1

rs1358030

0.32 (C)

0.11

0.07

0.13

1409

0.13

0.17

0.43

1408

GSC

rs11624318

0.78 (C)

0.03

0.08

0.75

1484

-0.14

0.18

0.45

1483

WDR72

rs566369

0.91 (G)

-0.21

0.12

0.06

1479

-0.29

0.27

0.29

1478

Combined SNP effect based upon an allele count score

0.04

0.04

0.38

1403

-0.05

0.1

0.66

1402

  1. All effect sizes represent the change in HbA1c or non-fasting serum glucose per risk allele. Age, sex and BMI were included as covariates in the regression models. P values are two-sided and are unadjusted for multiple testing.
  2. RAF: risk allele frequency