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Table 2 Genotype distribution and association of KCNQ1 SNPs with T2D

From: Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US

Punjabi Cohort (n = 2,355)

US Cohort (n = 710)

Combined (n = 3,065)**

SNP

Genotype

NG†(%)

T2D¥(%)

Odds Ratios (OR)* (95%CI) P-value

NG (%)

T2D (%)

Odds Ratios††(95%CI) P-value

NG (%)

T2D (%)

Odds Ratios††(95%CI) P-value

rs231362

GG

559 (54)

779 (60)

unadjusted

1.25 (1.09 - 1.43)

328 (58)

81 (57)

unadjusted

0.97 (0.72 - 1.29)

887 (56)

860 (60)

unadjusted

1.18 (1.05 - 1.33)

 

GA

395 (38)

437 (34)

0.001

191 (34)

49 (35)

0.823

586 (37)

486 (34)

0.005

 

AA

78 (8)

71 (6)

adjusted

1.24 (1.08 - 1.43)

42 (8)

11 (8)

adjusted

1.04 (0.75 - 1.45)

120 (7)

82 (6)

adjusted

1.21 (1.06 - 1.37)

 

Ψ G/A

0.73/0.27

0.78/0.22

0.002

0.75/0.25

0.75/0.25

0.798

0.74/0.26

0.77/0.23

0.004

rs2237892

CC

982 (96.3)

1259 (97.6)

unadjusted

1.49 (0.94 - 2.37)

523 (93.9)

133 (95.7)

unadjusted

1.48 (0.63 - 3.47)

1505 (95.5)

1392 (97.4)

unadjusted

1.74 (1.18 - 2.56)

 

CT

36 (3.5)

30 (2.3)

0.094

32 (5.7)

6 (4.3)

0.368

68 (4.3)

36 (2.5)

0.005

 

TT

1 (0.1)

1 (0.1)

adjusted

1.44 (0.89 - 2.31)

2 (0.4)

0 (0)

adjusted

2.35 (0.88 - 6.30)

3 (0.2)

1 (0.1)

adjusted

1.53 (1.01 - 2.32)

 

C/T

0.98/0.02

0.99/0.01

0.136

0.97/0.03

0.98/0.02

0.088

0.98/0.02

0.99/0.01

0.046

rs2237895

AA

359 (35)

410 (32)

unadjusted

1.11 (0.99 - 1.25)

206 (38)

40 (29)

unadjusted

1.32 (1.02 - 1.70)

565 (36)

450 (32)

unadjusted

1.15 (1.04 - 1.27)

 

AC

473 (46)

610 (47)

0.068

249 (45)

67 (48)

0.037

722 (46)

677 (48)

0.006

 

CC

188 (18)

265 (21)

adjusted

1.14 (1.01-1.28)

96 (17)

32 (23)

adjusted

1.24 (0.93 - 1.66)

284 (18)

297 (20)

adjusted

1.15 (1.03 - 1.29)

 

A/C

0.58/0.42

0.56/0.44

0.036

0.60/0.40

0.53/0.47

0.146

0.59/0.41

0.55/0.45

0.011

Meta-analysis

SNP

Risk Allele

P-value (Fixed Effect)

P-value (Random Effect)

OR (Fixed Effect)

OR (Random Effect)

P-value (Heterogeneity)

    

rs231362

G

0.009

0.390

1.15

1.11

0.114

    

rs2237892

C

0.030

0.030

1.37

1.37

0.522

    

rs2237895

C

0.018

0.021

1.14

1.14

0.313

    
  1. * Allelic ORs for Punjabi cohort were adjusted for age, sex, and BMI; †Normoglycemic; ¥ type II diabetes; Ψ letters in bold indicate risk allele; **Subjects with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) were excluded from analysis; Bonferroni p-value for three SNPs using 3 genetic models = 0.0055; †† ORs for US and combined analysis were adjusted for age, gender, BMI, and place of birth.
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BMC Medical Genetics

ISSN: 1471-2350

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