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Table 1 Clinical characteristics of study populations (Mean ± SD)

From: Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US

 

Punjabi Cohort

US Cohort

Combined

 

n = 2,431

n = 879

n = 3,310

Age (yrs.)

53.5 ± 12.9

48.0 ± 13.5

52.1 ± 13.3

% Males

52.5

51.7

52.3

Age at Diagnosis (yrs.)

47.6 ± 11.1

42.4 ± 18.9

47.4 ± 11.6

Duration of Diabetes (yrs.)

7.6 ± 6.8

6.8 ± 7.1

7.6 ± 6.8

BMI (kg/m2)

26.9 ± 5.1

26.9 ± 4.5

26.9 ± 5.0

Waist (cm)

93.2 ± 12.4

92.5 ± 13.4

93.0 ± 12.7

WHR

0.95 ± 0.07

0.90 ± 0.13*

0.94 ± 0.10

FBG (mg/dL)

   

Non-Diabetic

95.0 ± 13.4

98.5 ± 13.0

96.6 ± 13.3

Diabetic

162.7 ± 62.4

145.9 ± 42.7**

160.8 ± 60.4

2h glucose (mg/dL)

   

Non-Diabetic

107.1 ± 23.2

115.4 ± 24.8

111.4 ± 24.4

Diabetic

201.2 ± 69.2

228.2 ± 72.8¥

209.1 ± 71.3

Fasting Insulin (IU/mL)

6.6 (6.3 - 6.9)

7.4 (7.1 - 7.8)

6.8 (6.6 - 7.1)

HOMA-IR

2.1 (2.0 - 2.2)

1.9 (1.8 - 2.0)

2.0 (1.9 - 2.1)

HOMA-B

37.9 (35.5 - 40.4)

71.4 (67.5 - 75.5)φ

45.7 (43.5 - 48.1)

NG (%)

43.1

64.7

48.9

T2D (%)

53.8

16.0

43.7

IGT/IFG (%)

3.1

19.2

7.4

Normoglycemic; Type II Diabetes; Impaired glucose tolerance, Impaired fasting glucose. *p < 0.001; **p = 0.002; ¥p = 0.02 (showing significant difference in the Punjabi and US cohorts); φp = 4.64 × 10-8; Skewed variables (insulin, HOMA-IR and HOMA-B) are presented in mean (95% confidence intervals).