Genetic variation of Glucose Transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) Study

Table 5 Unadjusted and multivariate linear regression of ln (ACR) and serum creatinine for Enh 2 in all genotyped European Americans, by type 2 diabetes status.

	Regression coefficient forGLUT1 Enh2 Risk Genotype(TT) (95% CI) reference: (CC or CT)
(N = Enh2 TT Genotype/All Genotypes)	ln (ACR) ß Coefficient (95% CI)	P-value	Serum Creatinine ß Coefficient (95% CI)	P-value
TYPE 2 DIABETES (N = 72/1,095)
Unadjusted	0.26 (-0.17 - 0.69)	0.240	0.06 (-0.00 - 0.13)	0.069
Model 1	0.27 (-0.14 - 0.68)	0.196	0.02 (-0.04 - 0.09)	0.446
Model 2	0.28 (-0.13 - 0.68)	0.185	0.02 (-0.04 - 0.09)	0.446
NON-DIABETIC (N = 478/7,027)
Unadjusted	-0.02 (-0.12 - 0.09)	0.737	-0.01 (-0.04 - 0.01)	0.189
Model 1	-0.02 (-0.12 - 0.08)	0.702	-0.01 (-0.03 - 0.01)	0.146
Model 2	-0.02 (-0.12 - 0.08)	0.667	-0.01 (-0.03 - 0.00)	0.143

Model 1 includes age, sex, systolic blood pressure, diastolic blood pressure and hypertension medication use.
Model 2 includes Model 1 covariates and BMI and estimated glomerular filtration rate for the outcome ln (ACR). For the outcome of serum creatinine, model 2 includes Model 1 covariates and BMI.

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