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Table 2 Stage 1GLUT1 Enh2 and XbaI Risk genotype distributions among case and control subjects and odds ratio of albuminuria, by diabetes and race

From: Genetic variation of Glucose Transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) Study

 

European Americans

 

Type 2 Diabetes

No Type 2 Diabetes

SNP

Controls

Cases

P-value

OR (95% CI)

Controls

Cases

P-value

OR (95% CI)

Enh2 SNP (C > T)

480

84

   

1166

73

   

   CC or CT

(94.6)

(88.1)

0.025

1.00

 

(94.7)

(93.1)

0.574

1.00

 

   TT

(5.4)

(11.9)

 

2.36

(1.09 - 5.09)*

(5.3)

(6.9)

 

1.31

(0.51 - 3.36)

XbaI SNP (C > A) †

348

70

   

866

62

   

   CC or CA

(94.5)

(88.6)

0.064

1.00

 

(94.2)

(90.3)

0.212

1.00

 

   AA

(5.5)

(11.4)

 

2.23

(0.94 - 5.33)

(5.8)

(9.7)

 

1.75

(0.72 - 4.25)

 

African Americans

 

Type 2 Diabetes

No Type 2 Diabetes

SNP

Controls

Cases

P-value

OR (95% CI)

Controls

Cases

P-value

OR (95% CI)

Enh2 SNP (C > T)

217

80

   

770

68

   

   CC or CT

(99.5)

(100.0)

0.543

1.00

 

(99.7)

(100.0)

0.674

1.00

 

   TT

(0.5)

(0.0)

 

N/A

 

(0.3)

(0.0)

 

N/A

 

XbaI SNP (C > A) †

190

73

   

654

59

   

   CC or CA

(81.6)

(80.8)

0.888

1.00

 

(82.6)

(78.0)

0.376

1.00

 

   AA

(18.4)

(19.2)

 

1.05

(0.53 - 2.09)

(17.4)

(22.0)

 

1.34

(0.70 - 2.56)

  1. *P < 0.05.
  2. †Bonferroni correction requires p < 0.01 to reach statistical significance