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Figure 2 | BMC Medical Genetics

Figure 2

From: Genetic variation of Glucose Transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) Study

Figure 2

Macroalbuminuria, Enh2 risk genotypes and insulin concentrations among non-diabetic European Americans (n = 6629 (46 cases)). *P < 0.05. Among non-diabetic European Americans with fasting insulin, the risk of macroalbuminuria associated with the GLUT1 Enh2 TT risk genotype was 1.84, 95% CI: 0.71 - 4.77, P = 0.210, adjusting for age, gender, hypertension status, BMI, and GFR. For individuals in the upper quartile of insulin concentrations, the Enh2 TT genotype was associated with macroalbuminuria (OR 4.08, 95% CI: 1.06 - 15.61, p = 0.040) while it was not associated among those in the lower three quartiles (OR 1.00, 95% CI: 0.23 - 4.28, P = 0.995). There was no significant interaction between high concentrations of insulin and Enh2 TT genotypes on macroalbuminuria risk (P-interaction = 0.163).

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BMC Medical Genetics

ISSN: 1471-2350

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