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Figure 1 | BMC Medical Genetics

Figure 1

From: Genetic variation of Glucose Transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) Study

Figure 1

GLUT1 is located on chromosome 1p34.2. The genomic structure of GLUT1 is illustrated with its 10 exons and three putative enhancers[5]. Genotyped polymorphisms located in intron 2 include the intron-2 SNP (rs841858), and the Enh2(rs841847) and XbaI (rs841853) SNPs which have been previously associated with diabetic nephropathy[5–7]. In the distal promoter region, the Promoter SNP (rs841839) was genotyped (located between putative enhancers 3 and 1). We also included two SNPs in intron 1, intron-1 SNP(rs3768043) and intron-2 SNP(rs2297977). No SNP was associated with albuminuria among all African Americans or among all European Americans, including XbaI (p = 0.08) and Enh2 (p = 0.08). None of the tagging SNPs were able to reach a Bonferroni adjusted level of statistical significance. †Bonferroni corrected level of statistical significance p = 0.01.

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BMC Medical Genetics

ISSN: 1471-2350

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