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Table 3 Longitudinal analysis of amyloid β42 (Aβ42) plasma levels in different insulin degrading enzyme 2 (SNP rs4646953) genotypes

From: Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzymegene

IDE2 genotype

Aβ42plasma level [pg/ml]

 

slope (95% CI)

p-value

all genotypes

23.7 (20.34 - 27.07)

< 2 ∙ 10

only T/T

21.33 (17.73 - 24.94)

< 2 ∙ 10-16

only T/C

25.84 (16.52 - 35.17)

5.6 ∙ 10-8

only C/C

43.28 (27.7 - 58.86)

5.23 ∙ 10-8

  1. Effect sizes and nominal p-values were derived from multivariate regression analysis with sex and presence of apolipoprotein E (APOE ε4) alleles as covariates. All IDE2 (SNP rs4646953) genotype groups display a highly significant increase in Aβ42plasma concentration between each of the three examinations.
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BMC Medical Genetics

ISSN: 1471-2350

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