Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study

BMC Medical Genetics

Table 4 Top 5 independent* SNPs associated with renal sinus fat in women (above) and men (below)

Women									Results in men for top 5 SNPs observed in women
SNP	Chr	Position (Build 36)	Closest Gene	Effect Allele	Effect Allele Frequency	Imputation Score	β	P	β	P
rs2873333	2	236525509	*CENTG2*	C	0.43	0.69	-0.349	2.1E-07	0.069	0.17
rs17736767	5	98607864	CHD1	G	0.27	0.74	-0.340	2.3E-06	-0.080	0.14
rs17111435	11	109950861	ARHGAP20	G	0.08	1.00	0.462	2.6E-06	0.083	0.29
rs9375674	6	130258203	C6orf191	A	0.46	1.01	0.248	4.1E-06	0.087	0.04
rs2518144	12	8650712	*AICDA*	T	0.45	0.98	0.253	4.1E-06	0.046	0.26
Men									Results in women for top 5 SNPs observed in men
SNP	Chr	Position (Build 36)	Closest Gene	Effect Allele	Effect Allele Frequency	Imputation Score	β	P	β	P
rs2748531	14	23791741	TGM1	A	0.13	0.89	-0.299	3.6E-06	-0.126	0.14
rs13414916	2	159662666	*TANC1*	T	0.21	0.99	-0.231	5.4E-06	-0.082	0.23
rs11099681	4	149322904	*NR3C2*	C	0.27	1.01	0.207	5.8E-06	-0.053	0.39
rs12722875	1	116617007	ATP1A1	A	0.33	1.01	-0.190	1.3E-05	-0.005	0.93
rs12432394	14	21098781	OR10G3	T	0.20	0.78	-0.248	1.4E-05	-0.033	0.67

The β coefficients and p-values each of the top 5 SNPs in the opposite sex are presented in the far right columns.
β coefficients for the association separately in women and men for cohort-specific residuals of natural log-transformed renal sinus fat, adjusted for age and BMI.
Nearby genes based on RefSeq genes (build 36). The gene is presented in boldface if the SNP is located within the gene.
* Independent SNPs defined as those with r² < 0.2 at any locus

ISSN: 1471-2350