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Table 6 Additive interaction between IL13 polymorphisms and smoking

From: Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

 

Smoking status

 

No

Yes

SNP

Adjusted OR (95% CI)*

Adjusted OR (95% CI)*

rs1800925

  

   CC + CT

1.00

0.98 (0.74 - 1.31)

   TT

0.78 (0.32 - 1.89)

2.67 (0.70 - 10.17)

   Measures of additive interaction†

Relative excess risk due to interaction (RERI) = 1.90 (95% CI: -1.71 - 5.52)

Attributable proportion due to interaction (AP) = 0.71 (95% CI: 0.25 - 1.18)

Synergy index (S) = -6.97 (95% CI: not calculable)

rs20541

  

   GG + GA

1.00

0.96 (0.71 - 1.29)

   AA

1.34 (0.78 - 2.29)

2.34 (1.10 - 4.98)

   Measures of additive interaction†

Relative excess risk due to interaction (RERI) = 1.05 (95% CI: -0.82 - 2.91)

Attributable proportion due to interaction (AP) = 0.45 (95% CI: -0.07 - 0.96)

Synergy index (S) = 4.52 (95% CI: 0.25 - 83.47)

  1. * Adjusted for age, region of residence, presence of older siblings, family history of allergic rhinitis, and education.
  2. † Statistically significant with the 95% CI of RERI > 0, the 95% CI of AP > 0, or the 95% CI of S > 1, indicating additive interaction.