Analysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19

Table 3 Significantly associated haplotypes in PEPD and CD22 genes

Gene and SNPs in the haplotype	Alleles	Haplotype	Haplotype
			Frequency in cases	Frequency in controls	OR [95% CI]	P-value
PEPD
		[CTTCA]	0.328	0.367	Reference
rs10500265	C/G	[CTCCA]	0.136	0.154	1.049 [0.761, 1.445]
rs6510383	C/T	[CTTCG]	0.066	0.068	1.062 [0.687, 1.644]
rs7248389	C/T	[CCCCA]	0.115	0.096	1.422 [0.997, 2.028]	0.0026
rs7250833	C/T	[CTCCG]	0.021	0.013	1.872 [0.745, 4.706]
rs2241380	A/G	[GCCTG]	0.095	0.075	1.512 [1.020, 2.242]
		[CTCTG]	0.226	0.188	1.435 [1.087, 1.894]
CD22
rs756796	A/G	[GA]	0.105	0.147	0.716 [0.528,0.971]
rs2267574	A/T	[GT]	0.615	0.623	Reference	0.0065
		[AT]	0.280	0.230	1.253 [0.995, 1.577]

The most common haplotype was used as a reference (OR of 1) and the other haplotypes were compared to that.

ISSN: 1471-2350