Day 45 Change from Baseline | Â | Â | Â | Â | Â | Â | ||
---|---|---|---|---|---|---|---|---|
gene | SNP | Allele | AC1202 | n | Placebo | n | p-value* | Difference(CI) |
IDE | IDE- | IDE c/c (-) | -2.772 | 19 | 2.071 | 23 | 0.000 | 4.843(2.568, 7.118) |
IDE | IDE+ | IDE c/c (+) | 0.667 | 4 | -0.667 | 1 | 0.745 | 1.333(-6.870, 9.536) |
IDE | rs2251101 | C | 0.667 | 4 | -0.667 | 1 | 0.744 | 1.333(-6.867, 9.534) |
IDE | rs2251101 | Het | -4.500 | 6 | 1.775 | 12 | 0.001 | 6.275(2.608, 9.942) |
IDE | rs2251101 | T | -1.974 | 13 | 2.394 | 11 | 0.005 | 4.368(1.364, 7.373) |
IL1B | rs1143627 | C | 0.333 | 3 | 4.333 | 3 | 0.192 | 4.000(-2.103, 10.103) |
IL1B | rs1143627 | Het | -2.083 | 8 | 0.524 | 7 | 0.180 | 2.607(-1.261, 6.476) |
IL1B | rs1143627 | T | -3.633 | 10 | 1.997 | 13 | 0.001 | 5.631(2.487, 8.775) |
IL1B | rs16944 | C | -3.633 | 10 | 1.997 | 13 | 0.001 | 5.631(2.487, 8.775) |
IL1B | rs16944 | Het | -2.083 | 8 | 0.524 | 7 | 0.180 | 2.607(-1.261, 6.476) |
IL1B | rs16944 | T | 0.333 | 3 | 4.333 | 3 | 0.192 | 4.000(-2.103, 10.103) |
Day 90 Change from Baseline | Â | Â | Â | Â | Â | Â | ||
IDE | IDE- | IDE c/c (-) | -3.729 | 16 | 2.156 | 19 | 0.003 | 5.885(2.192, 9.578) |
IDE | IDE+ | IDE c/c (+) | 3.583 | 4 | -5.333 | 1 | 0.146 | 8.917(-3.252, 21.086) |
IDE | rs2251101 | C | 3.583 | 4 | -5.333 | 1 | 0.132 | 8.917(-2.834, 20.667) |
IDE | rs2251101 | Het | -7.733 | 5 | 2.956 | 9 | 0.001 | 10.689(4.827, 16.551) |
IDE | rs2251101 | T | -1.909 | 11 | 1.437 | 10 | 0.148 | 3.346(-1.246, 7.938) |
IL1B | rs1143627 | C | -1.000 | 3 | 3.222 | 3 | 0.370 | 4.222(-5.241, 13.685) |
IL1B | rs1143627 | Het | -0.250 | 8 | -0.389 | 6 | 0.964 | 0.139(-6.120, 6.398) |
IL1B | rs1143627 | T | -5.667 | 8 | 2.463 | 10 | 0.005 | 8.130(2.633, 13.627) |
IL1B | rs16944 | C | -5.667 | 8 | 2.463 | 10 | 0.005 | 8.130(2.633, 13.627) |
IL1B | rs16944 | Het | -0.250 | 8 | -0.389 | 6 | 0.964 | 0.139(-6.120, 6.398) |
IL1B | rs16944 | T | -1.000 | 3 | 3.222 | 3 | 0.370 | 4.222(-5.241, 13.685) |
Day 104 Change from Baseline | Â | Â | Â | Â | Â | Â | ||
IDE | IDE- | IDE c/c (-) | -1.909 | 22 | 1.686 | 21 | 0.026 | 3.595(0.451, 6.739) |
IDE | IDE+ | IDE c/c (+) | 4.833 | 4 | -3.333 | 1 | 0.160 | 8.167(-3.356, 19.690) |
IDE | rs2251101 | C | 4.833 | 4 | -3.333 | 1 | 0.152 | 8.167(-3.117, 19.451) |
IDE | rs2251101 | Het | -4.546 | 8 | 0.867 | 10 | 0.028 | 5.413(0.625, 10.200) |
IDE | rs2251101 | T | -0.402 | 14 | 2.430 | 11 | 0.167 | 2.833(-1.234, 6.899) |
IL1B | rs1143627 | C | 1.444 | 3 | -0.333 | 3 | 0.670 | 1.778(-6.598, 10.153) |
IL1B | rs1143627 | Het | 0.478 | 9 | 1.611 | 6 | 0.674 | 1.133(-4.273, 6.540) |
IL1B | rs1143627 | T | -3.333 | 12 | 0.894 | 12 | 0.048 | 4.228(0.040, 8.415) |
IL1B | rs16944 | C | -3.333 | 12 | 0.894 | 12 | 0.048 | 4.228(0.040, 8.415) |
IL1B | rs16944 | Het | 0.478 | 9 | 1.611 | 6 | 0.674 | 1.133(-4.273, 6.540) |
IL1B | rs16944 | T | 1.444 | 3 | -0.333 | 3 | 0.670 | 1.778(-6.598, 10.153) |